Shopping Cart
Remove All
Your shopping cart is currently empty
Clozapine
Copy Product Info
😃Good
Catalog No. T0455Cas No. 5786-21-0
Alias LX 100-129, HF 1854
Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.
Clozapine
Copy Product Info😃Good
Purity: 99.93%
Catalog No. T0455Alias LX 100-129, HF 1854Cas No. 5786-21-0
Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $30 | In Stock | In Stock | |
| 25 mg | $42 | In Stock | In Stock | |
| 50 mg | $61 | In Stock | In Stock | |
| 100 mg | $92 | In Stock | In Stock | |
| 500 mg | $302 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $37 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.93%
Color:White to Yellow
Contact us for more batch information
Product Introduction
Clozapine AI Summary
Clozapine exhibits a wide range of pharmacological activities across various receptor systems and demonstrates significant potential for therapeutic implications. It shows high affinity for serotonin 5-hydroxytryptamine receptors 2A (Ki = 3.68 nM) and 2C (Ki = 10.47 nM), as well as dopamine receptors, particularly D4 (Ki = 10.0 nM) and D2 (Ki = 223.87 nM). The compound displays strong binding to adrenergic alpha-1 receptors (Ki = 1.4 nM) and muscarinic acetylcholine receptors (IC50 = 12.0 nM). It inhibits multiple behaviors induced by apomorphine and DOI in rodent models, with effective doses ranging from 2.2 mg/kg to approximately 26.2 mg/kg. Clozapine shows moderate liver distribution (Vdss = 5.4 L/kg), low unbound fraction in plasma (Fu = 0.05), and significant metabolic stability. Additionally, it also affects the heart by inhibiting the human ERG channel (IC50 = 323.59 nM). Despite its wide receptor interactions, including histamine H1 and various dopamine and serotonin receptors, its potential therapeutic application in conditions related to adrenergic, dopaminergic, and serotonergic signaling, and its detailed pharmacokinetic profile make it a compound of considerable interest for further investigation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. |
| Targets&IC50 | M4 mAChR:11 nM (EC50, agonist), α2-adrenoceptor:51 nM (Ki, inhibitor), M1 mAChR:9.5 nM(Ki), D2 Receptor:75 nM (Ki, antagonist), 5-HT2A receptor:4 nM (Ki, inhibitor) |
| In vitro | Clozapine significantly facilitated NMDA-evoked responses in a concentration-dependent manner (EC50: 14 nM).Clozapine produced excitatory postsynaptic potentials, which were blocked by glutamate receptor antagonists, suggesting that these excitatory postsynaptic potentials were the result of an increased release of excitatory amino acids.Clozapine is a full agonist at muscarinic M4 receptors, with an EC50=11 nM, and a -logEC50=6.52.The EC50=11 nM. Clozapine is a full agonist at muscarinic M4 receptors, with an EC50=11 nM, and inhibits forskolin-stimulated cAMP accumulation.Clozapine is a potent antagonist of agonist-induced responses at four other muscarinic receptor subtypes. |
| In vivo | Clozapine significantly facilitated NMDA-evoked responses in a concentration-dependent manner (EC50: 14 nM).Clozapine produced excitatory postsynaptic potentials, which were blocked by glutamate receptor antagonists, suggesting that these excitatory postsynaptic potentials were the result of an increased release of excitatory amino acids.Clozapine is a full agonist at muscarinic M4 receptors, with an EC50=11 nM, and a -logEC50=6.52.The EC50=11 nM. Clozapine is a full agonist at muscarinic M4 receptors, with an EC50=11 nM, and inhibits forskolin-stimulated cAMP accumulation.Clozapine is a potent antagonist of agonist-induced responses at four other muscarinic receptor subtypes. |
| Synonyms | LX 100-129, HF 1854 |
| Molecular Weight | 326.82 |
| Formula | C18H19ClN4 |
| Cas No. | 5786-21-0 |
| Smiles | CN1CCN(CC1)C1=NC2=C(NC3=C1C=CC=C3)C=CC(Cl)=C2 |
| Relative Density. | 1.31 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 82.5 mg/mL (252.43 mM), Sonication is recommended.  2eq.HCl: 16.3 mg/mL (49.87 mM), Heating is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.12 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
2eq.HCl/DMSO
DMSO
| |||||||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Clozapine | purchase Clozapine | Clozapine cost | order Clozapine | Clozapine chemical structure | Clozapine in vivo | Clozapine in vitro | Clozapine formula | Clozapine molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.