Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 184.00 | |
50 μg | 5 days | $ 545.00 | |
500 μg | 5 days | $ 1,900.00 | |
1 mg | 5 days | $ 2,730.00 |
Description | Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade. |
Species | Human |
Expression System | E. coli |
Tag | N-6His |
Accession Number | Q9UHA4 |
Synonyms | Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1, LAMTOR3, Mp1, Ragulator Complex Protein LAMTOR3, Mitogen-Activated Protein Kinase Scaffold Protein 1, Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3, MEK-Binding Partner 1, M |
Amino Acid | Met1-Ser124 |
Construction | Recombinant Human Mitogen-Activated Protein Kinase Scaffold Protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser124 is expressed with a 6His tag at the N-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 15 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 5mM DTT, 30% Glycerol, pH 8.0. |
Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Shipping |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade. |
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Mp1 Protein, Human, Recombinant (His) Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1 LAMTOR3 LAMTOR-3 Mp1 Ragulator Complex Protein LAMTOR3 Mitogen-Activated Protein Kinase Scaffold Protein 1 Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3 MEK-Binding Partner 1 M LAMTOR 3 recombinant recombinant-proteins proteins protein