Shopping Cart

Your shopping cart is currently empty

Amiodarone hydrochloride

Name: Amiodarone hydrochloride
Brand: TargetMol
SKU: T1496
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1496Cas No. 19774-82-4

Alias Nexterone, Amiodarone HCl, Amiodar HCl

Amiodarone hydrochloride is an anti-anginal agent and a class III antiarrhythmic drug that inhibits potassium channels (including wild-type hERG channels and their tail currents, with an IC₅₀ of approximately 45 nM) as well as voltage-gated sodium channels. This leads to prolonged action potential duration in ventricular and atrial myocytes, resulting in reduced heart rate and vascular resistance. It activates ERK1/2 and p38 MAPK signaling pathways in fibroblasts, promoting cell proliferation and myofibroblast differentiation. Amiodarone hydrochloride is widely used in the study of supraventricular and ventricular arrhythmias and can also be used to establish pulmonary fibrosis animal models.

Amiodarone hydrochloride

Copy Product Info

🥰Excellent

Purity: 99.86%

Catalog No. T1496Alias Nexterone, Amiodarone HCl, Amiodar HClCas No. 19774-82-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$36	In Stock	In Stock
1 g	$47	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Amiodarone hydrochloride AI Summary

Amiodarone hydrochloride exhibits a range of bioactivities across various biological systems and conditions. It shows colloidal aggregation in fed state simulated intestinal fluid, indicated by dynamic light scattering assays at 2 µM concentrations in the presence of 1% DMSO. It inhibits Trypanosoma cruzi cruzaine, with IC50 values of 206,000 nM with Triton X-100 and 4,000 nM without. It also exhibits antiplasmodial activity against multiple Plasmodium falciparum strains with IC50 values ranging from 1,995 nM to 7,943 nM after 72-hour exposure. Additionally, it affects cell viability in HPDE-C7 and HPDE-C7K cells with EC50 values of 6,530 nM and 7,820 nM, respectively, and shows inhibitory effects on various tumor cell lines with GI50 values from 7,726 nM to 11,015 nM. Amiodarone hydrochloride inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with specific inhibition rates at given concentrations and times. It also displays antifungal activity against Candida albicans and Cryptococcus neoformans with a MIC of 10,000 nM but lacks significant antibacterial activity against several bacterial strains. The compound has low cytotoxicity against HEK293 cells (CC50 > 10,000 nM) and affects the thermal stability of various protein domains, indicating complex interactions. Additionally, it influences protein-protein interactions and cellular functions associated with cancer and pathogen inhibition. The pharmacokinetic profile of the compound includes high protein binding, moderate bioavailability, and a long half-life. Notably, Amiodarone hydrochloride, identified as Amiodarone hydrochloride, also displays vasodilative activity in rat aorta preparations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Amiodarone hydrochloride is an anti-anginal agent and a class III antiarrhythmic drug that inhibits potassium channels (including wild-type hERG channels and their tail currents, with an IC₅₀ of approximately 45 nM) as well as voltage-gated sodium channels. This leads to prolonged action potential duration in ventricular and atrial myocytes, resulting in reduced heart rate and vascular resistance. It activates ERK1/2 and p38 MAPK signaling pathways in fibroblasts, promoting cell proliferation and myofibroblast differentiation. Amiodarone hydrochloride is widely used in the study of supraventricular and ventricular arrhythmias and can also be used to establish pulmonary fibrosis animal models.
Targets&IC50	K+-ATP channel:19.1 μM
In vitro	Amiodarone (AM) inhibits the intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5'-deiodination (5'DI) without affecting the intracellular conversion from T4 to reverse T3 (rT3).1.25-25 mg/kg Amiodarone in the AV node and in anaesthetized dogs resulted in a decrease in sinus rate, a prolongation of the AV node effective and functional occlusion of the AV node, as well as frequency-dependent conduction delays. 50 mg/kg daily for 3-4 weeks Amiodarone in rabbit ventricular myocytes resulted in a significant reduction in iK and ito current densities without affecting ICA and IK1 densities.
In vivo	Amiodarone penetrates deeply into the lipid matrix of the membrane and is released very slowly from cardiac tissue during washout.Amiodarone inhibits fast sodium channels as well as slow calcium channels.Amiodarone also has non-competitive antiarrhythmic effects and regulates thyroid function and phospholipid metabolism.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells. Amiodarone inhibits Vmax in papillary muscle without affecting the resting membrane potential, and this Vmax inhibition is potentiated in a frequency- or use-dependent manner as is the case with class I antiarrhythmic drugs.50-88 μM Amiodarone inhibits depolarization-induced spontaneous action potentials (aberrant automaticity) in ventricular myocardium and Purkinje fibers.50-88 μM Amiodarone inhibits depolarization induced action potentials (aberrant automaticity) in human ventricular muscle.
Synonyms	Nexterone, Amiodarone HCl, Amiodar HCl

Chemical Properties

Molecular Weight	681.78
Formula	C₂₅H₂₉I₂NO₃·HCl
Cas No.	19774-82-4
Smiles	Cl.c1(c2c(oc1CCCC)cccc2)C(=O)c1cc(c(c(c1)I)OCCN(CC)CC)I
Relative Density.	1.58 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.73 mg/mL (33.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4667 mL	7.3337 mL	14.6675 mL	73.3374 mL
5 mM	0.2933 mL	1.4667 mL	2.9335 mL	14.6675 mL
10 mM	0.1467 mL	0.7334 mL	1.4667 mL	7.3337 mL
20 mM	0.0733 mL	0.3667 mL	0.7334 mL	3.6669 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc