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CK1-IN-1

🥰Excellent
Catalog No. T5393Cas No. 1784751-20-7
Alias PUN51207

CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.

CK1-IN-1

CK1-IN-1

🥰Excellent
Purity: 98.79%
Catalog No. T5393Alias PUN51207Cas No. 1784751-20-7
CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$42In StockIn Stock
2 mg$59In StockIn Stock
5 mg$98In StockIn Stock
10 mg$163In StockIn Stock
25 mg$322In StockIn Stock
50 mg$496In StockIn Stock
100 mg$745In StockIn Stock
1 mL x 10 mM (in DMSO)$108In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.79%
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Product Introduction

Bioactivity
Description
CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.
Targets&IC50
CK1ε:16 nM (cell free), p38σ MAPK:73 nM (cell free), CK1δ:15 nM (cell free)
SynonymsPUN51207
Chemical Properties
Molecular Weight383.39
FormulaC24H15F2N3
Cas No.1784751-20-7
SmilesFc1ccc(cc1)-c1nc([nH]c1-c1ccncc1)-c1ccc2ccccc2c1F
Relative Density.1.310 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (156.5 mM), Sonication is recommended.
H2O: Insoluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6083 mL13.0416 mL26.0831 mL130.4155 mL
5 mM0.5217 mL2.6083 mL5.2166 mL26.0831 mL
10 mM0.2608 mL1.3042 mL2.6083 mL13.0416 mL
20 mM0.1304 mL0.6521 mL1.3042 mL6.5208 mL
50 mM0.0522 mL0.2608 mL0.5217 mL2.6083 mL
100 mM0.0261 mL0.1304 mL0.2608 mL1.3042 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PUN-51207PUN 51207p38σ MAPKp38MAPKp38 MAPKInhibitorinhibitCK1-IN-1CK-1-IN-1CK1IN1CK1 IN 1CK1CaseinKinaseCasein Kinase
Related Tags: buy CK1-IN-1 | purchase CK1-IN-1 | CK1-IN-1 cost | order CK1-IN-1 | CK1-IN-1 chemical structure | CK1-IN-1 formula | CK1-IN-1 molecular weight
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