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Bergenin (Synonyms: Cuscutin, Bengenin)

Name: Bergenin
Brand: TargetMol
SKU: T0122
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T0122 Copy Product Info

Purity: 99.60%

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Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.

Bergenin

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Catalog No. T0122

Synonyms Cuscutin, Bengenin

Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.

Cas No. 477-90-7

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.60%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bergenin AI Summary

Bergenin exhibits a broad spectrum of bioactivities that include growth inhibition of various cancer cell lines such as human BGC823, MCF7, HepG2, SGC7901, A549, and PC3 cells, indicating potential cytotoxic effects. It has demonstrated significant antiviral activity, notably against HIV-1 by reducing antigen gp120 production with an EC50 of 40.0 µg/mL and against SARS-CoV-2 by inhibiting induced cytotoxicity in Caco-2 and VERO-6 cells, as well as inhibiting SARS-CoV-2 3CL-Pro protease. In addition to its antiproliferative and antiviral properties, Bergenin shows antibacterial effects against several bacterial strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae) and possesses significant anti-inflammatory capabilities by reducing superoxide anion and NO production in human neutrophils and mouse J774.2 cells, respectively. Moreover, it exhibits antioxidant activities, notable ACNE inhibitory activities, and stimulates lipolysis in Wistar rat fat cells. Its inhibitory activities extend to enzymes such as Sporosarcina pasteurii urease (IC50 = 21,700.0 nM), mushroom tyrosinase, electric eel acetylcholinesterase, and human HDAC6. Additionally, it impacts transport functions in OATP1B1 and OATP1B3-transfected CHO cells by inhibiting sodium fluorescein uptake. Bergenin also shows significant antiglycation activities by inhibiting Schiff-base formation and glycated end product formation in bovine serum albumin assays. It exhibits moderate stability in various pH buffers and biological fluids and demonstrates solubility in water and different buffers up to concentrations greater than 1000.0 µg/mL, with a low partition coefficient (LogP = -1.06). These varied bioactivities suggest that Bergenin holds potential for multiple therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Targets&IC50	Viability (HeLa cervical cancer cells):15 µM
Synonyms	Cuscutin, Bengenin

Chemical Properties

Molecular Weight	328.27
Formula	C₁₄H₁₆O₉
Cas No.	477-90-7
Smiles	[H][C@]12OC(=O)c3cc(O)c(OC)c(O)c3[C@]1([H])O[C@H](CO)[C@@H](O)[C@@H]2O
Relative Density.	1.639 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 237.5 mg/mL (723.49 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0463 mL	15.2314 mL	30.4627 mL	152.3136 mL
5 mM	0.6093 mL	3.0463 mL	6.0925 mL	30.4627 mL
10 mM	0.3046 mL	1.5231 mL	3.0463 mL	15.2314 mL
20 mM	0.1523 mL	0.7616 mL	1.5231 mL	7.6157 mL
50 mM	0.0609 mL	0.3046 mL	0.6093 mL	3.0463 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	1.5231 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc