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Anti-CALML3 Antibody (1W13)

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Catalog No. TMAY-02365
Alias CLP, calmodulin-like 3

Anti-CALML3 Antibody (1W13) is a Mouse antibody targeting CALML3. Anti-CALML3 Antibody (1W13) can be used in FCM.

Anti-CALML3 Antibody (1W13)

Anti-CALML3 Antibody (1W13)

😃Good
Catalog No. TMAY-02365Alias CLP, calmodulin-like 3
Anti-CALML3 Antibody (1W13) is a Mouse antibody targeting CALML3. Anti-CALML3 Antibody (1W13) can be used in FCM.
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100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-CALML3 Antibody (1W13) is a Mouse antibody targeting CALML3. Anti-CALML3 Antibody (1W13) can be used in FCM.
AliasCLP, calmodulin-like 3
Ig Type
Monoclonal Mouse IgG1
Clone
1W13
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human CALML3 expression on A431 cells.  The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human CALML3, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis product is a recombinant monoclonal antibody expressed from HEK293 cells.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundCalmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a tumor-sensitive protein specifically expressed in normal epithelial cells but downregulated in tumorigenesis. Downregulation of the protein is an early event in breast cancer development. One of the most pressing questions raised by the discovery of CLP/CALML3 is that of its potential targets. Although it is 85% identical to human calmodulin, the distinct properties of CLP suggest that it has specific targets or targets that only partially overlap with those of calmodulin. Research has identified the unconventional myosin-10 (Myo10) as a specific target of CALML3. The discovery of Myo10 as a specific target of CALML3 is highly significant and suggests multiple lines of further research such as investigations of the Ca2+ regulation of Myo10 and the role of the loss of CLP in epithelial differentiation, adhesion, and cancer. Cells expressing CALML3 displayed a striking increase in the number and length of myosin-10-positive filopodia and showed increased mobility in a wound healing assay.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human CALML3 Protein (TMPY-02760)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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