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AT-56

Name: AT-56
Brand: TargetMol
SKU: T1866
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1866Cas No. 162640-98-4

AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.

AT-56

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Purity: 99.5%

Catalog No. T1866Cas No. 162640-98-4

AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$252	In Stock	In Stock
50 mg	$419	In Stock	In Stock
100 mg	$662	In Stock	In Stock
200 mg	$926	-	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.5%

Color:White to Yellow

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COA

Product Introduction

AT-56 AI Summary

AT-56 has been tested for cell viability using various cell lines, showing diverse effects. In HEK293T cells, growth rates ranged from 0.42 to 0.94, while in U2OS cells, the growth rates were recorded at 0.4 and 0.89. Notably, in human fibroblast cells, a negative growth rate of -0.99 was observed. These findings indicate that AT-56 has the potential to both stimulate and inhibit cell viability, depending on the cell type. Additionally, the compound influences protein thermal stability, decreasing stability for domains such as M1-K294, M1-S360, E122-S403, S229-K512, G626-G740, G861-E979, and N44-E168, while increasing stability for domains like M1-L298, M26-R383, and P449-E759. These effects suggest that AT-56 might modulate protein function or interactions through its impact on thermal stability..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.
Targets&IC50	L-PGDS:95 μM (IC50), L-PGDS:Ki: 75 μM

Chemical Properties

Molecular Weight	397.52
Formula	C₂₅H₂₇N₅
Cas No.	162640-98-4
Smiles	C(CCc1nn[nH]n1)CN1CCC(CC1)=C1c2ccccc2C=Cc2ccccc12
Relative Density.	1.216 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 23.81 mg/mL (59.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5156 mL	12.5780 mL	25.1560 mL	125.7798 mL
5 mM	0.5031 mL	2.5156 mL	5.0312 mL	25.1560 mL
10 mM	0.2516 mL	1.2578 mL	2.5156 mL	12.5780 mL
20 mM	0.1258 mL	0.6289 mL	1.2578 mL	6.2890 mL
50 mM	0.0503 mL	0.2516 mL	0.5031 mL	2.5156 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc