DcR2/TRAIL R4 Protein, Human, Recombinant (His)

Catalog No. TMPY-01381 Copy Product Info

DcR2/TRAIL R4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is Q9UBN6.

DcR2/TRAIL R4 Protein, Human, Recombinant (His)

Catalog No. TMPY-01381

Copy Product Info

DcR2/TRAIL R4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is Q9UBN6.

Pack Size	Price	USA Stock	Global Stock
5 μg	$48	7-10 days	7-10 days
10 μg	$76	7-10 days	7-10 days
20 μg	$118	7-10 days	7-10 days
50 μg	$237	7-10 days	7-10 days
100 μg	$458	7-10 days	7-10 days
200 μg	$693	7-10 days	7-10 days
500 μg	$1,450	7-10 days	7-10 days
1 mg	$2,930	7-10 days	7-10 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Information

Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF10D at 10 μg/ml (100 μl/well) can bind biotinylated TNFSF10 with a linear range of 0.625-40 ng/ml.
Description	DcR2/TRAIL R4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is Q9UBN6.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q9UBN6
Synonyms	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain,TRUNDD,TRAIL-R4,TRAILR4,DCR2,CD264
Construction	A DNA sequence encoding the human TNFRSF10D (NP_003831.2) extracellular domain (Met 1-His 211) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 56
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	18.4 kDa (predicted); 30-40 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.