DDR2 Protein, Human, Recombinant (T654M, GST)

Catalog No. TMPC-00203 Copy Product Info

DDR2 Protein, Human, Recombinant (T654M, GST) is expressed in Baculovirus-Insect Cells. The accession number is Q16832.

DDR2 Protein, Human, Recombinant (T654M, GST)

Catalog No. TMPC-00203

Copy Product Info

DDR2 Protein, Human, Recombinant (T654M, GST) is expressed in Baculovirus-Insect Cells. The accession number is Q16832.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 μg	$1,350	35 days	35 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of DDR2 (T654M) was determined to be 5 nmol /min/mg by radioactive kinase assay.
Description	DDR2 Protein, Human, Recombinant (T654M, GST) is expressed in Baculovirus-Insect Cells. The accession number is Q16832.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	Q16832
Synonyms	TYRO10,TKT,NTRKR3,Discoidin domain-containing receptor 2,Discoidin domain receptor 2,DDR2,CD167b
Construction	Recombinant human DDR2 (T654M) (467-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>95% as determined by SDS-PAGE.
Molecular Weight	~70 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy