TGF-beta 1 Protein, Bovine, Recombinant

Name: TGF-beta 1 Protein, Bovine, Recombinant
Brand: TargetMol
SKU: TMPS-00133
Rating: 4.5 (1 reviews)

(Synonyms: transforming growth factor beta-1, TGF-beta-1, TGF-beta 1 protein, TGF-b1, TGFB1, TGFB, TGF beta, latency-associated peptide, DPD1, CEDLAP, CED) Copy Product Info

Synonyms: transforming growth factor beta-1, TGF-beta-1, TGF-beta 1 protein, TGF-b1, TGFB1, TGFB, TGF beta, latency-associated peptide, DPD1, CEDLAP, CED

Catalog No. TMPS-00133 Copy Product Info

TGF-beta 1 Protein, Bovine, Recombinant is expressed in CHO Cells. The accession number is P18341.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$198	7-10 days	7-10 days
10 µg	$339	7-10 days	7-10 days
20 µg	$515	7-10 days	7-10 days
50 µg	$883	7-10 days	7-10 days
100 µg	$1,380	7-10 days	7-10 days
200 µg	$2,130	7-10 days	7-10 days
500 µg	$3,820	7-10 days	7-10 days
1 mg	$5,930	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 0.2 ng/ml, measured in ability to inhibit the mouse IL-4-dependent proliferation of HT-2 cells.
Description	TGF-beta 1 Protein, Bovine, Recombinant is expressed in CHO Cells. The accession number is P18341.
Species	Bovine
Expression System	CHO Cells
Tag	Tag Free
Accession Number	P18341
Construction	Ala279-Ser390
Protein Purity	≥ 95% as determined by SDS-PAGE
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in 50 mM NaAc, 50 mM NaCl, pH 5.0.
Reconstitution	It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH 2 O or 50 mM Citrate up to 100 μg/ml.
Synonyms	transforming growth factor beta-1, TGF-beta-1, TGF-beta 1 protein, TGF-b1, TGFB1, TGFB, TGF beta, latency-associated peptide, DPD1, CEDLAP, CED
Research Background	TGF-β1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-β1 superfamily that share a characteristic cystine knot structure. TGF-β1, -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-β isoform has some non-redundant function; for TGF-β1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation. TGF-β1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-β RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-β RI (also called activin receptor‑like kinase (ALK)-5), or alternatively, ALK-1. This complex phosphorylates and activates Smad proteins that regulate transcription.

Chemical Properties

Molecular Weight

12.8 kDa (monomer, predicted); 12 kDa (reducing conditions)

Storage & Solubility Information

Shipping

In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.

Storage

Upon receiving, this product remains stable for up to 6 months at lower than -70 °C. Upon reconstitution, the product should be stable for up to 1 week at 4 °C or up to 3 months at -20 °C. For long-term storage after reconstitution, it is recommended that a carrier protein (e.g., 0.1% BSA) be added. Avoid repeated freeze-thaw cycles by making single-use aliquots before the solution is stored at -20 °C.