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Triton X-100

Catalog No. T64297 CAS 9002-93-1

Triton X-100 is a non-denaturing detergent that solubilizes lipid membranes. Triton X-100 is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Triton X-100 is listed as an excipient in certain vaccines including split virus influenza vaccines. Triton X-100 is a nonionic surfactant [1] [2].

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Triton X-100, CAS 9002-93-1

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100 g	In stock	$ 42.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Triton X-100 is a non-denaturing detergent that solubilizes lipid membranes. Triton X-100 is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Triton X-100 is listed as an excipient in certain vaccines including split virus influenza vaccines. Triton X-100 is a nonionic surfactant [1] [2].
In vitro	Triton X-100 (ranging from 0.5% to 0.05%; 1 h; Vero E6 cells) obtained with WNV showed that infectivity was reduced by 6 Logs. This effect was not time-dependent using 0.1% Triton X-100. We applied the method to EBOV and one-hour exposure to 0.1% Triton X-100 strongly affected EBOV infectivity (4 Logs of infectivity reduction).[3]

Molecular Weight	208.26
Formula	C14H12N2
CAS No.	9002-93-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (216.08 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Herman SM, et al. The hidden allergen: Triton X-100, a derivative of polyethylene glycol. J Allergy Clin Immunol Pract. 2021;9(7):2941. 2. Ghosh R, et al. Unraveling diverse action of triton X-100 and methimazole on lysozyme fibrillation/aggregation: Physicochemical insights. Int J Biol Macromol. 2021;167:736-745. 3. Colavita F, et al. Evaluation of the inactivation effect of Triton X-100 on Ebola virus infectivity. J Clin Virol. 2017;86:27-30. 4. Vrestkin AP, et al. Effect of Triton X-100 on properties of acetylcholinesterase from human erythrocytes. Biokhimiia. 1978;43(1):94-99.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Triton X-100 9002-93-1 inhibitor inhibit

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