Shopping Cart

Your shopping cart is currently empty

Neuromedin B

Name: Neuromedin B
Brand: TargetMol
SKU: TP1442
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. TP1442Cas No. 87096-84-2

Neuromedin B (NMB) is one of the bombesin (BN)-related peptides in mammals. It was originally purified from pig spinal cords, and it has been shown to be present in central nervous system as well as in gastrointestinal tract.

Neuromedin B

Copy Product Info

🥰Excellent

Purity: 99.39%

Catalog No. TP1442Cas No. 87096-84-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$536	In Stock	In Stock
25 mg	$868	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,590	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.39%

Appearance:Solid

Color:White

Resource Download

COA LCMS

Product Introduction

Neuromedin B AI Summary

Neuromedin B exhibits a range of bioactivities and binding affinities across different receptors and assays. It is notably effective against the neuromedin B receptor (NMB-R) in CHO cells with an EC50 of 120.0 nM, and against the gastrin-releasing peptide receptor (GRP-R) in CHO cells with an EC50 of 41.0 nM. Additionally, it demonstrates activity against the human bombesin receptor 3 (BRS-3) in CHO cells with an EC50 of 4500.0 nM. In terms of antagonism, Neuromedin B shows high activity against the recombinant human bombesin receptor (bb1) with a Ki of 0.068 nM and moderate binding affinity at the Bombesin BB2 receptor with a Ki of 56.0 nM. Furthermore, Neuromedin B demonstrates inhibitory activity in two specific assays: against Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 17782.8 nM and against N370S glucocerebrosidase as a potential chaperone treatment for Gaucher Disease with a potency of 7079.5 nM. In displacement assays, it displaces [125I]-BBN from GRPR in human PC3 cells with an IC50 value greater than 500.0 nM and displaces [125I]-NMB from the NMB receptor in rat C6 cells with an IC50 value of 0.7 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	1132.29
Formula	C₅₂H₇₃N₁₅O₁₂S
Cas No.	87096-84-2
Smiles	C([C@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC(N)=O)=O)CC(C)C)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC1=CN=CN1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)[C@@H](C)O)=O)C)=O)C=3C=4C(NC3)=CC=CC4
Relative Density.	1.337 g/cm3
Sequence	Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
Sequence Short	GNLWATGHFM

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (110.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8832 mL	4.4158 mL	8.8317 mL	44.1583 mL
5 mM	0.1766 mL	0.8832 mL	1.7663 mL	8.8317 mL
10 mM	0.0883 mL	0.4416 mL	0.8832 mL	4.4158 mL
20 mM	0.0442 mL	0.2208 mL	0.4416 mL	2.2079 mL
50 mM	0.0177 mL	0.0883 mL	0.1766 mL	0.8832 mL
100 mM	0.0088 mL	0.0442 mL	0.0883 mL	0.4416 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc