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PRX-07034 hydrochloride

Name: PRX-07034 hydrochloride
Brand: TargetMol
SKU: T8720
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8720Cas No. 903580-39-2

Alias PRX-07034 HCL

PRX-07034 hydrochloride is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 hydrochloride is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors.

PRX-07034 hydrochloride

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Purity: 98.5%

Catalog No. T8720Alias PRX-07034 HCLCas No. 903580-39-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$38	In Stock	In Stock
25 mg	$71	In Stock	In Stock
50 mg	$118	In Stock	In Stock
100 mg	$191	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.5%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	PRX-07034 hydrochloride is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 hydrochloride is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors.
Targets&IC50	5-HT6 receptor:4-8 nM (Ki), 5-HT1D receptor:2.8 μM (Ki), 5-HT6 receptor:19 nM (IC50), 5-HT1B receptor:260 nM (Ki), D3 receptor:71 nM (Ki), μ opioid receptor:0.45 μM (Ki), 5-HT2A receptor:2.5 μM (IC50), 5-HT2B receptor:2.5 μM (IC50), 5-HT2C receptor:3.7 μM (IC50), 5-HT1A receptor:420 nM (Ki), H2 receptor:0.64 μM (Ki)
In vitro	PRX-07034 is a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist with 100-fold selectivity over 68 other GPCRs, ion channels, and transporters, except for D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors. It demonstrated antagonist activity in cyclic AMP quantification (IC(50) = 19 nM) without affecting basal levels and showed no agonist activity up to 10 μM. At doses of 1 and 3 mg/kg, PRX-07034 significantly enhanced delayed spontaneous alternation and switching between place and response strategies, but did not affect initial learning of place or response discrimination.
Synonyms	PRX-07034 HCL

Chemical Properties

Molecular Weight	490.44
Formula	C₂₁H₂₉Cl₂N₃O₄S
Cas No.	903580-39-2
Smiles	Cl.COc1cc(Cl)cc(C(C)Nc2cc(ccc2S(C)(=O)=O)N2CCNCC2)c1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (20.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0390 mL	10.1949 mL	20.3899 mL	101.9493 mL
5 mM	0.4078 mL	2.0390 mL	4.0780 mL	20.3899 mL
10 mM	0.2039 mL	1.0195 mL	2.0390 mL	10.1949 mL
20 mM	0.1019 mL	0.5097 mL	1.0195 mL	5.0975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc