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Integrin modulator 1

Catalog No. T36291 CAS 2023788-32-9

Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1].

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Integrin modulator 1, CAS 2023788-32-9

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 332.00
25 mg	6-8 weeks	$ 1,080.00
50 mg	6-8 weeks	$ 1,410.00
100 mg	6-8 weeks	$ 1,990.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 318.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1].
Targets&IC50	α4β1:9.8 nM (IC50)
In vitro	Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells[1].Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner[1].

Molecular Weight	262.26
Formula	C13H14N2O4
CAS No.	2023788-32-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (381.30 mM)

References and Literature

1. Baiula M, et, al. New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. J Med Chem. 2016 Nov 10;59(21):9721-9742.

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Keywords

Integrin modulator 1 2023788-32-9 inhibitor inhibit

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