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Integrin modulator 1

Name: Integrin modulator 1
Brand: TargetMol
SKU: T36291
Rating: 4.5 (1 reviews)

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Catalog No. T36291Cas No. 2023788-32-9

Integrin modulator 1 is a potent and selective α4β1 integrin agonist with an IC50 value of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 enhances cell adhesion mediated by α4β1 integrin with an EC50 of 12.9 nM, highlighting its utility in studying integrin-dependent adhesion processes.

Integrin modulator 1

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Purity: 99.61%

Catalog No. T36291Cas No. 2023788-32-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$332	6-8 weeks	6-8 weeks
25 mg	$1,080	6-8 weeks	6-8 weeks
50 mg	$1,410	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$318	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Appearance:Solid

Color:White

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COA LCMS CNMR HNMR

Product Introduction

Bioactivity

Description	Integrin modulator 1 is a potent and selective α4β1 integrin agonist with an IC50 value of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 enhances cell adhesion mediated by α4β1 integrin with an EC50 of 12.9 nM, highlighting its utility in studying integrin-dependent adhesion processes.
Targets&IC50	α4β1:9.8 nM
In vitro	Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells.Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner.[1]

Chemical Properties

Molecular Weight	262.26
Formula	C₁₃H₁₄N₂O₄
Cas No.	2023788-32-9
Smiles	O=C(O)CC1N(C(=O)NC=2C=CC=CC2C)C(=O)C1
Relative Density.	1.413 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (305.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (19.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8130 mL	19.0650 mL	38.1301 mL	190.6505 mL
5 mM	0.7626 mL	3.8130 mL	7.6260 mL	38.1301 mL
10 mM	0.3813 mL	1.9065 mL	3.8130 mL	19.0650 mL
20 mM	0.1907 mL	0.9533 mL	1.9065 mL	9.5325 mL
50 mM	0.0763 mL	0.3813 mL	0.7626 mL	3.8130 mL
100 mM	0.0381 mL	0.1907 mL	0.3813 mL	1.9065 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc