Shopping Cart

Your shopping cart is currently empty

Abaloparatide acetate

Name: Abaloparatide acetate
Brand: TargetMol
SKU: TP1215L
Price: 36 EUR
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Abaloparatide acetate (247062-33-5 free base)) Copy Product Info

🥰Excellent

Synonyms: Abaloparatide acetate (247062-33-5 free base)

Catalog No. TP1215L Copy Product Info

Purity: 95.66%

🥰Excellent

Abaloparatide acetate is a parathyroid hormone receptor 1 PTHR1 analogue and an effective and selective activator of the PTHR1 signaling pathway.

Pack Size	Price	EUR Stock	Global Stock
1 mg	36 €	-	In Stock
5 mg	106 €	-	In Stock
10 mg	166 €	-	In Stock
25 mg	270 €	-	In Stock
50 mg	376 €	-	In Stock
100 mg	505 €	-	In Stock

For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:95.66%

Appearance:solid

Color:White

Resource Download

COA HPLC MS

Product Information

Bioactivity

Description	Abaloparatide acetate is a parathyroid hormone receptor 1 PTHR1 analogue and an effective and selective activator of the PTHR1 signaling pathway.
In vitro	MC3T3-E1 osteoblast cells are treated with 0.01-100 nM ofAbaloparatide acetate for 40 min at 37 ℃ in the presence of 0.5 mM IBMX. The Result reveals that exposure of cells toAbaloparatide acetate caused a robust elevation of intracellular cAMP levels.Abaloparatide acetate treatment Result in a 2.3-fold decrease in EC₅₀ value for cAMP formation compared to teriparatide (EC₅₀s of 0.3 nM and 0.7 nM, respectively)^[1]. A dose-dependent stimulation of β-arrestin/PTHR1 interaction is demonstrated byAbaloparatide acetate. Consistently, the calculates the EC₅₀ value forAbaloparatide acetate is 1.6-fold lower than that of teriparatide (EC₅₀s of 0.9 nM and 1.5 nM, respectively)^[1].Abaloparatide acetate efficiently induces a dose-dependent stimulation of PTHR1 internalization with a dose as low as 0.1 nM and reaches maximum stimulation at 100 nM concentration. The EC₅₀ value of 0.8 nM forAbaloparatide acetate^[1].
In vivo	Abaloparatide acetate (1-25 μg/kg; subcutaneous injection; daily; for 12 months; female Sprague-Dawley rats) treatment increases biochemical bone formation markers, histomorphometric indices of bone formation on trabecular, endocortical, and periosteal surfaces.Abaloparatide acetate acetate induces substantial increases in trabecular bone volume and density and improvements in trabecular microarchitecture.Abaloparatide acetate acetate stimulates periosteal expansion and endocortical bone apposition at the tibial diaphysis, leading to marked increases in cortical bone volume and density. Whole-body bone mineral density (BMD) is increasing 25% after 12 months ofAbaloparatide acetate acetate (25?μg/kg) in osteopenic ovariectomized (OVX) rats^[2].
Synonyms	Abaloparatide acetate (247062-33-5 free base)

Chemical Properties

Molecular Weight	4020.71
Formula	C₁₇₆H₃₀₄N₅₆O₅₁
Smiles	C[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC([C@H](CC1=CNC=N1)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(C(C)(C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CC2=CNC=N2)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CC3=CNC=N3)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH₂
Sequence Short	AVSEHQLLHDKGKSIQDLRRRELLEKLLXKLHTA

Storage & Solubility Information

Storage

Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.5 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2487 mL	1.2436 mL	2.4871 mL	12.4356 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Parathyroid hormone receptor 1Abaloparatide acetate(247062-33-5 free base)Abaloparatide acetate(247062335 free base)Abaloparatide acetate(247062 33 5 free base)

Related Tags: Abaloparatide acetate chemical structure | Abaloparatide acetate in vivo | Abaloparatide acetate in vitro | Abaloparatide acetate formula | Abaloparatide acetate molecular weight