HVEM Protein, Rhesus macaque, Recombinant (hFc)

HVEM Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A0A2K5W0R1.

Pack Size	Availability	Price/USD
10 μg	5 days	$ 85.00
50 μg	5 days	$ 184.00
500 μg	5 days	$ 825.00
1 mg	5 days	$ 1,180.00

Pack Size

Availability

Price/USD

Quantity

10 μg

5 days

$ 85.00

50 μg

5 days

$ 184.00

500 μg

5 days

$ 825.00

1 mg

5 days

$ 1,180.00

Description

HVEM Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A0A2K5W0R1.

Species	Rhesus macaque
Expression System	Human Cells
Tag	C-Fc
Accession Number	A0A2K5W0R1
Synonyms	CD270, TNFRSF14, TR2, Herpesvirus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, Herpes Virus Entry Mediator A, HVEM, Tumor Necrosis Factor Receptor Superfamily Member 14, HVEA
Amino Acid	Pro37-Val203
Construction	Recombinant Rhesus Macaque Herpesvirus Entry Mediator is produced by our Mammalian expression system and the target gene encoding Pro37-Val203 is expressed with a human IgG1 Fc tag at the C-terminus.
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	60 KDa, reducing conditions

Endotoxin	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Stability & Storage	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background	Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

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HVEM Protein, Rhesus macaque, Recombinant (hFc)

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