HVEM Protein, Rhesus macaque, Recombinant (hFc)

Name: HVEM Protein, Rhesus macaque, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-01416
Rating: 4.5 (1 reviews)

(Synonyms: Tumor Necrosis Factor Receptor-Like 2, Tumor Necrosis Factor Receptor Superfamily Member 14, TR2, TNFRSF14, HVEM, HVEA, Herpesvirus Entry Mediator A, Herpes Virus Entry Mediator A, CD270) Copy Product Info

Synonyms: Tumor Necrosis Factor Receptor-Like 2, Tumor Necrosis Factor Receptor Superfamily Member 14, TR2, TNFRSF14, HVEM, HVEA, Herpesvirus Entry Mediator A, Herpes Virus Entry Mediator A, CD270

Catalog No. TMPJ-01416 Copy Product Info

HVEM Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A0A2K5W0R1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$54	35 days	35 days
10 µg	$85	35 days	35 days
20 µg	$118	35 days	35 days
50 µg	$183	35 days	35 days
100 µg	$287	35 days	35 days
200 µg	$449	35 days	35 days
500 µg	$825	35 days	35 days
1 mg	$1,180	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	HVEM Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A0A2K5W0R1.
Species	Rhesus
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	A0A2K5W0R1
Amino Acid	Pro37-Val203
Construction	Pro37-Val203
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Tumor Necrosis Factor Receptor-Like 2, Tumor Necrosis Factor Receptor Superfamily Member 14, TR2, TNFRSF14, HVEM, HVEA, Herpesvirus Entry Mediator A, Herpes Virus Entry Mediator A, CD270
Research Background	Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

Chemical Properties

Molecular Weight

60 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.