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CDDO-dhTFEA

🥰Excellent
Catalog No. T13604Cas No. 1191265-33-4

CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).

CDDO-dhTFEA

CDDO-dhTFEA

🥰Excellent
Purity: 99.59%
Catalog No. T13604Cas No. 1191265-33-4
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).
Pack SizePriceAvailabilityQuantity
1 mg$64In Stock
2 mg$93In Stock
5 mg$155In Stock
10 mg$268In Stock
25 mg$538In Stock
50 mg$777In Stock
100 mg$1,090In Stock
500 mg$2,170In Stock
1 mL x 10 mM (in DMSO)$197In Stock
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Purity:99.59%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).
In vivo
CDDO-dhTFEA restores hypertension, increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis, and inflammation in the chronic kidney disease rats [2].
Chemical Properties
Molecular Weight574.72
FormulaC33H45F3N2O3
Cas No.1191265-33-4
Smiles[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC(F)(F)F
Relative Density.1.20 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (174.00 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7400 mL8.6999 mL17.3998 mL86.9989 mL
5 mM0.3480 mL1.7400 mL3.4800 mL17.3998 mL
10 mM0.1740 mL0.8700 mL1.7400 mL8.6999 mL
20 mM0.0870 mL0.4350 mL0.8700 mL4.3499 mL
50 mM0.0348 mL0.1740 mL0.3480 mL1.7400 mL
100 mM0.0174 mL0.0870 mL0.1740 mL0.8700 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

RTA dh-404RTA dh404RTA dh 404Nuclear factor-κBNuclear factor-kappaBNrf2NF-κBNFκBNF-kBNFkBKeap1-Nrf2InhibitorinhibitCDDO-dhTFEACDDOdhTFEACDDO dhTFEA
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