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NB-598 Maleate

Name: NB-598 Maleate
Brand: TargetMol
SKU: T12199
Rating: 4.5 (1 reviews)

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Catalog No. T12199Cas No. 155294-62-5

NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.

NB-598 Maleate

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Catalog No. T12199Cas No. 155294-62-5

NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$626	1-2 weeks	1-2 weeks
50 mg	$814	1-2 weeks	1-2 weeks
100 mg	$1,320	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.

In vitro

NB-598, an inhibitor of squalene epoxidase, on cholesterol absorption from the intestinal epithelia.?NB-598 (10 microM) inhibited the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG).?When labeled lipid was apically loaded as a micellar lipid solution into Caco-2 cell cultures, NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG[1].

Chemical Properties

Molecular Weight	565.74
Formula	C₃₁H₃₅NO₅S₂
Cas No.	155294-62-5
Smiles	OC(=O)\C=C/C(O)=O.CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCc2cc(cs2)-c2ccsc2)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (176.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7676 mL	8.8380 mL	17.6760 mL	88.3798 mL
5 mM	0.3535 mL	1.7676 mL	3.5352 mL	17.6760 mL
10 mM	0.1768 mL	0.8838 mL	1.7676 mL	8.8380 mL
20 mM	0.0884 mL	0.4419 mL	0.8838 mL	4.4190 mL
50 mM	0.0354 mL	0.1768 mL	0.3535 mL	1.7676 mL
100 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.8838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc