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Diquat (bromide)

Catalog No. T37519   CAS 85-00-7

Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Formulations containing diquat have been used in agriculture for crop desiccation and defoliation.

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Diquat (bromide) Chemical Structure
Diquat (bromide), CAS 85-00-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Formulations containing diquat have been used in agriculture for crop desiccation and defoliation.
Molecular Weight 264.145
Formula C12H12BrN2
CAS No. 85-00-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1 mg/mL

Ethanol: Slightly soluble

TargetMolReferences and Literature

1. Moreland, D.E.Mechanisms of action of herbicidesAnn. Rev. Plant Physiol.31597-638(1980) 2. Cao, S., Wu, H., Wang, C., et al.Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in pigletsJ. Anim. Sci.96(5)1795-1805(2018) 3. Singh, P., Hanson, P.S., and Morris, C.M.Sirtuin-2 protects neural cells from oxidative stress and is elevated in neurodegenerationParkinsons Dis.2017:2643587(2017) 4. Tomá?ek, O., Gabrielová, B., Ka?er, P., et al.Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signallingSci. Rep.6:23546(2016)

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Keywords

Diquat (bromide) 85-00-7 Diquat inhibitor inhibit

 

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