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Biotin-PEG4-amine

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Catalog No. T14599Cas No. 663171-32-2

Biotin-PEG4-amine is a biotinylated PEGylated amine linker that provides a flexible spacer suitable for PROTAC synthesis and bioconjugation workflows. Biotin-PEG4-amine facilitates efficient ligand attachment to proteins or small molecules via its terminal amine while preserving accessibility for streptavidin-based detection or enrichment techniques.

Biotin-PEG4-amine

Biotin-PEG4-amine

😃Good
Purity: 98.84%
Catalog No. T14599Cas No. 663171-32-2
Biotin-PEG4-amine is a biotinylated PEGylated amine linker that provides a flexible spacer suitable for PROTAC synthesis and bioconjugation workflows. Biotin-PEG4-amine facilitates efficient ligand attachment to proteins or small molecules via its terminal amine while preserving accessibility for streptavidin-based detection or enrichment techniques.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 mg$35-In Stock
500 mg$80-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.84%
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Product Introduction

Bioactivity
Description
Biotin-PEG4-amine is a biotinylated PEGylated amine linker that provides a flexible spacer suitable for PROTAC synthesis and bioconjugation workflows. Biotin-PEG4-amine facilitates efficient ligand attachment to proteins or small molecules via its terminal amine while preserving accessibility for streptavidin-based detection or enrichment techniques.
In vitro
PROTACs comprise two ligands linked together: one binds an E3 ubiquitin ligase, and the other targets a specific protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Chemical Properties
Molecular Weight462.6
FormulaC20H38N4O6S
Cas No.663171-32-2
SmilesC(CCCC(NCCOCCOCCOCCOCCN)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
Relative Density.1.161 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (172.94 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1617 mL10.8085 mL21.6169 mL108.0847 mL
5 mM0.4323 mL2.1617 mL4.3234 mL21.6169 mL
10 mM0.2162 mL1.0808 mL2.1617 mL10.8085 mL
20 mM0.1081 mL0.5404 mL1.0808 mL5.4042 mL
50 mM0.0432 mL0.2162 mL0.4323 mL2.1617 mL
100 mM0.0216 mL0.1081 mL0.2162 mL1.0808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PEGsBiotin-PEG4-amineBiotin-PEG-4-amineBiotinPEG4amineBiotin PEG4 amine
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