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Biotin-PEG4-amine

Name: Biotin-PEG4-amine
Brand: TargetMol
SKU: T14599
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14599Cas No. 663171-32-2

Biotin-PEG4-amine is a biotinylated PEGylated amine linker that provides a flexible spacer suitable for PROTAC synthesis and bioconjugation workflows. Biotin-PEG4-amine facilitates efficient ligand attachment to proteins or small molecules via its terminal amine while preserving accessibility for streptavidin-based detection or enrichment techniques.

Biotin-PEG4-amine

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Purity: 98.84%

Catalog No. T14599Cas No. 663171-32-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$35	-	In Stock
500 mg	$80	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.84%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Biotin-PEG4-amine is a biotinylated PEGylated amine linker that provides a flexible spacer suitable for PROTAC synthesis and bioconjugation workflows. Biotin-PEG4-amine facilitates efficient ligand attachment to proteins or small molecules via its terminal amine while preserving accessibility for streptavidin-based detection or enrichment techniques.
In vitro	PROTACs comprise two ligands linked together: one binds an E3 ubiquitin ligase, and the other targets a specific protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	462.6
Formula	C₂₀H₃₈N₄O₆S
Cas No.	663171-32-2
Smiles	C(CCCC(NCCOCCOCCOCCOCCN)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
Relative Density.	1.161 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (172.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1617 mL	10.8085 mL	21.6169 mL	108.0847 mL
5 mM	0.4323 mL	2.1617 mL	4.3234 mL	21.6169 mL
10 mM	0.2162 mL	1.0808 mL	2.1617 mL	10.8085 mL
20 mM	0.1081 mL	0.5404 mL	1.0808 mL	5.4042 mL
50 mM	0.0432 mL	0.2162 mL	0.4323 mL	2.1617 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc