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Bilobetin

Name: Bilobetin
Brand: TargetMol
SKU: T4S2128
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4S2128Cas No. 521-32-4

Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.

Bilobetin

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Purity: 99.69%

Catalog No. T4S2128Cas No. 521-32-4

Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$64	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$447	In Stock	In Stock
50 mg	$646	In Stock	In Stock
100 mg	$888	-	In Stock
1 mL x 10 mM (in DMSO)	$196	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.69%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bilobetin AI Summary

Bilobetin demonstrates a variety of bioactivities, making it a candidate for multiple therapeutic applications. In mouse primary osteoblasts, it enhances ALP activity at 1 uM, 10 uM, and 20 uM concentrations, suggesting osteogenic potential. It inhibits human Cathepsin K with an IC50 of 0.84 ug/mL, indicating a role in mitigating bone resorption. The compound shows significant inhibition (84.0%) of Phosphodiesterase in rat adipose tissue, with an IC50 value of 360.0 nM, enhancing its credentials as a PDE inhibitor. As an inhibitor of BACE1 enzyme, it has an IC50 value of 2020.0 nM, potentially impacting Alzheimer's disease-related pathways. It also acts non-competitively against SARS coronavirus 3C-like protease with an IC50 of 72300.0 nM and a Ki of 80400.0 nM, showing antiviral promise. Bilobetin displays antimicrobial activity against Leishmania donovani amastigotes with an IC50 of 2700.0 nM. Neuroprotective effects are indicated by 44.7% cell viability in amyloid beta 42-treated rat PC12 cells. The compound exhibits low cytotoxicity to various human cell lines but shows moderate inhibition of human MMP9 with an IC50 of 10330.0 nM. It prevents amyloid beta (1 to 40) aggregation with an IC50 of 4700.0 nM and demonstrates cytotoxic activity against MCF7 cells with an IC50 of 26500.0 nM. In HCT-116 cells, the compound induces cell cycle arrest and apoptosis at concentrations of 10 uM and 20 uM after 24 and 48 hours, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.

Chemical Properties

Molecular Weight	552.48
Formula	C₃₁H₂₀O₁₀
Cas No.	521-32-4
Smiles	COc1ccc(cc1-c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Relative Density.	1.576 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (271.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8100 mL	9.0501 mL	18.1002 mL	90.5010 mL
5 mM	0.3620 mL	1.8100 mL	3.6200 mL	18.1002 mL
10 mM	0.1810 mL	0.9050 mL	1.8100 mL	9.0501 mL
20 mM	0.0905 mL	0.4525 mL	0.9050 mL	4.5251 mL
50 mM	0.0362 mL	0.1810 mL	0.3620 mL	1.8100 mL
100 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.9050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc