Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in FLT3-ITD+ acute myeloid leukemia (AML) cells. It promotes the ubiquitin-proteasome-dependent degradation of FLT3-ITD and KIT proteins, thereby effectively inhibiting their downstream signaling pathways and presenting research potential in FLT3-ITD+ AML [1].
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Description | Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in FLT3-ITD+ acute myeloid leukemia (AML) cells. It promotes the ubiquitin-proteasome-dependent degradation of FLT3-ITD and KIT proteins, thereby effectively inhibiting their downstream signaling pathways and presenting research potential in FLT3-ITD+ AML [1]. |
Molecular Weight | 747.77 |
Formula | C39H38FN9O6 |
CAS No. | 2732969-67-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Pomalidomide-C5-Dovitinib 2732969-67-2 PROTAC PROTACs inhibitor inhibit