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Complement C4-B Protein, Human, Recombinant (His & SUMO)

Catalog No. TMPH-01131
Synonyms: C4B, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Basic complement C4, Complement C4-B, CPAMD3, CO4

Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Complement C4-B Protein, Human, Recombinant (His & SUMO)
Pack Size Availability Price/USD Quantity
20 μg 20 days $ 198.00
100 μg 20 days $ 389.00
1 mg 20 days $ 1,680.00
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Biological Description
Technical Params
Product Properties
Description Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
Species Human
Expression System E. coli
Tag N-terminal 6xHis-SUMO-tagged
Accession Number P0C0L5
Synonyms C4B, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Basic complement C4, Complement C4-B, CPAMD3, CO4
Amino Acid EAPKVVEEQESRVHYTVCIWRNGKVGLSGMAIADVTLLSGFHALRADLEKLTSLSDRYVSHFETEGPHVLLYFDSVPTSRECVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAEGKCPRQRRALERGLQDEDGYRMKFACYYPRVEYGFQVKVLREDSRAAFRLFETKITQVLHFTKDVKAAANQMRNFLVRASCRLRLEPGKEYLIMGLDGATYDLEGHPQYLLDSNSWIEEMPSERLCRSTRQRAACAQLNDFLQEYGTQGCQV Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Construction 1454-1744 aa
Protein Purity > 90% as determined by SDS-PAGE.
Molecular Weight 49.1 kDa as predicted
Formulation Tris-based buffer,50% glycerol
Reconstitution A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

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Keywords

Complement C4-B Protein, Human, Recombinant (His & SUMO) C4B C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 Basic complement C4 Complement C4-B CPAMD3 CO4 recombinant recombinant-proteins proteins protein

 

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