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RI-2

Name: RI-2
Brand: TargetMol
SKU: T2628
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2628Cas No. 1417162-36-7

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

RI-2

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Purity: 99.86%

Catalog No. T2628Cas No. 1417162-36-7

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
2 mg	$98	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$296	In Stock	In Stock
25 mg	$458	In Stock	In Stock
50 mg	$673	In Stock	-
100 mg	$958	In Stock	-
1 mL x 10 mM (in DMSO)	$178	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:orange

Resource Download

COA HPLC HNMR

Product Introduction

RI-2 AI Summary

RI-2 exhibits cytotoxicity against HEK293 cells with an LD50 of 70.16 µM after 24 hours. Additionally, it inhibits the binding of human RAD51 to single-stranded DNA with an IC50 of approximately 44170.0 nM, as determined by a fluorescence polarization assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.
Targets&IC50	RAD51:44.17 μM

Chemical Properties

Molecular Weight	433.28
Formula	C₂₁H₁₈Cl₂N₂O₄
Cas No.	1417162-36-7
Smiles	COc1ccc(cc1)C1=C(N2CCOCC2)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1
Relative Density.	1.441 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (115.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3080 mL	11.5399 mL	23.0798 mL	115.3988 mL
5 mM	0.4616 mL	2.3080 mL	4.6160 mL	23.0798 mL
10 mM	0.2308 mL	1.1540 mL	2.3080 mL	11.5399 mL
20 mM	0.1154 mL	0.5770 mL	1.1540 mL	5.7699 mL
50 mM	0.0462 mL	0.2308 mL	0.4616 mL	2.3080 mL
100 mM	0.0231 mL	0.1154 mL	0.2308 mL	1.1540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc