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RI-2

Name: RI-2
Brand: TargetMol
SKU: T2628
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2628Cas No. 1417162-36-7

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

RI-2

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Purity: 99.86%

Catalog No. T2628Cas No. 1417162-36-7

RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.

Pack Size	Price	Availability
1 mg	$67	In Stock
2 mg	$98	In Stock
5 mg	$163	In Stock
10 mg	$296	In Stock
25 mg	$458	In Stock
50 mg	$673	In Stock
100 mg	$958	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Batch Information

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Purity:99.86%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.
Targets&IC50	RAD51:44.17 μM

Chemical Properties

Molecular Weight	433.28
Formula	C₂₁H₁₈Cl₂N₂O₄
Cas No.	1417162-36-7
Smiles	COc1ccc(cc1)C1=C(N2CCOCC2)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1
Relative Density.	1.441 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (115.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3080 mL	11.5399 mL	23.0798 mL	115.3988 mL
5 mM	0.4616 mL	2.3080 mL	4.6160 mL	23.0798 mL
10 mM	0.2308 mL	1.1540 mL	2.3080 mL	11.5399 mL
20 mM	0.1154 mL	0.5770 mL	1.1540 mL	5.7699 mL
50 mM	0.0462 mL	0.2308 mL	0.4616 mL	2.3080 mL
100 mM	0.0231 mL	0.1154 mL	0.2308 mL	1.1540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc