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Pep2-8

Name: Pep2-8
Brand: TargetMol
SKU: TP1881
Price: 109 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Pep 2-8) Copy Product Info

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Synonyms: Pep 2-8

Catalog No. TP1881 Copy Product Info

Purity: 97.24%

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Pep2-8 specifically inhibits PCSK9 activity with a KD of 0.7 μM and an IC50 of 1.4 μM.

Cas No. 1541011-97-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$109	-	In Stock
5 mg	$247	-	In Stock
10 mg	$400	-	In Stock
25 mg	$668	-	In Stock
50 mg	$939	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.24%

Appearance:Solid

Color:White

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COA MS HPLC

Product Introduction

Bioactivity

Description	Pep2-8 specifically inhibits PCSK9 activity with a KD of 0.7 μM and an IC50 of 1.4 μM.
Targets & IC50	PCSK9:0.7 μM (Kd), PCSK9:1.4 μM
In vitro	Methods: Molecular binding experiments were conducted to verify the binding effect between Pep2-8 and C-terminally truncated PCSK9. A lipid metabolism damage model was established by treating HepG2 cells with PCSK9, and after treatment with 50 μM Pep2-8, the changes in the low-density lipoprotein (LDL) uptake capacity of the cells were detected. Results: Pep2-8 could specifically bind to the C-terminally truncated PCSK9. At a working concentration of 50 μM, Pep2-8 effectively reversed the abnormal cell function induced by PCSK9, restoring the LDL uptake capacity of HepG2 cells to approximately 90% of that in the control group [1].
In vivo	Methods: The binding ability between peptide Pep2-8 and C-terminally truncated PCSK9 was explored. HepG2 cells were treated with PCSK9 to induce functional damage, then treated with 50 μM Pep2-8, and the recovery of LDL uptake function of the cells was detected. Results: Pep2-8 could specifically bind to the C-terminally truncated PCSK9 in a targeted manner. After intervention with 50 μM Pep2-8, the LDL uptake capacity of HepG2 cells damaged by PCSK9 was significantly recovered, reaching approximately 90% of the activity of the normal control group [1].
Synonyms	Pep 2-8

Chemical Properties

Molecular Weight	1715.85
Formula	C₈₃H₁₁₀N₁₆O₂₄
Cas No.	1541011-97-5
Smiles	[H][C@](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(N)=O
Relative Density.	1.357 g/cm3 (Predicted)
Sequence	Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂
Sequence Short	TVFTSWEEYLDWV

Storage & Solubility Information

Storage

Keep away from moistureKeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.4): 2 mg/mL (1.17 mM), Sonication is recommended.

DMSO: 80 mg/mL (46.62 mM)

Solution Preparation Table

PBS (pH 7.4)/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5828 mL	2.9140 mL	5.8280 mL	29.1401 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.1166 mL	0.5828 mL	1.1656 mL	5.8280 mL
10 mM	0.0583 mL	0.2914 mL	0.5828 mL	2.9140 mL
20 mM	0.0291 mL	0.1457 mL	0.2914 mL	1.4570 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

Pep2-8Pep-2-8Pep28Pep2 8

Related Tags: Pep2-8 chemical structure | Pep2-8 in vivo | Pep2-8 in vitro | Pep2-8 formula | Pep2-8 molecular weight