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PKUMDL-WQ-2201

Name: PKUMDL-WQ-2201
Brand: TargetMol
SKU: T28425
Rating: 4.5 (1 reviews)

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Catalog No. T28425Cas No. 592474-91-4

Alias PKUMDL-WQ2201

PKUMDL-WQ-2201 is a PHGDH non-NAD⁺-competing allosteric inhibitor with micromolar potency against wild-type and mutant PHGDH enzymes, effectively suppressing de novo serine biosynthesis in cancer cells and reducing tumor growth, PKUMDL-WQ-2201 provide a metabolic intervention strategy for studying serine-dependent tumor metabolism.

PKUMDL-WQ-2201

😃Good

Catalog No. T28425Alias PKUMDL-WQ2201Cas No. 592474-91-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$82	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PKUMDL-WQ-2201 is a PHGDH non-NAD⁺-competing allosteric inhibitor with micromolar potency against wild-type and mutant PHGDH enzymes, effectively suppressing de novo serine biosynthesis in cancer cells and reducing tumor growth, PKUMDL-WQ-2201 provide a metabolic intervention strategy for studying serine-dependent tumor metabolism.
In vitro	In PHGDH-amplified breast cancer cell lines such as MDA-MB-468, treatment with PKUMDL-WQ-2201 effectively inhibited serine synthesis and suppressed cell proliferation with GI50 values ranging from 6 to 20 μM. This antiproliferative effect was accompanied by the induction of apoptosis in the treated cells [1].
Synonyms	PKUMDL-WQ2201

Chemical Properties

Molecular Weight	351.81
Formula	C₁₅H₁₄ClN₃O₃S
Cas No.	592474-91-4
Smiles	O=C(O)C=1C=CC(=CC1Cl)C=2OC(C=NNC(=S)NCC)=CC2
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (227.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8424 mL	14.2122 mL	28.4244 mL	142.1222 mL
5 mM	0.5685 mL	2.8424 mL	5.6849 mL	28.4244 mL
10 mM	0.2842 mL	1.4212 mL	2.8424 mL	14.2122 mL
20 mM	0.1421 mL	0.7106 mL	1.4212 mL	7.1061 mL
50 mM	0.0568 mL	0.2842 mL	0.5685 mL	2.8424 mL
100 mM	0.0284 mL	0.1421 mL	0.2842 mL	1.4212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc