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3,5-Diiodothyropropionic acid

Name: 3,5-Diiodothyropropionic acid
Brand: TargetMol
SKU: T13492
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13492Cas No. 1158-10-7

Alias Ditpa cpd, C082182

3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1).

3,5-Diiodothyropropionic acid

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Purity: 98.42%

Catalog No. T13492Alias Ditpa cpd, C082182Cas No. 1158-10-7

3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$119	In Stock	In Stock
50 mg	$176	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.42%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

3,5-Diiodothyropropionic acid AI Summary

3,5-Diiodothyropropionic acid exhibits multiple bioactivities, including inhibition of human recombinant PCNA interaction with the PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK, with an IC50 value of 32000 nM determined by fluorescence polarization assay. It demonstrates antiviral activity against SARS-CoV-2 by reducing SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with an inhibition of 0.67% at 10 µM concentration in Caco-2 cells after 48 hours and varying degrees of inhibition in VERO-6 cells. Additionally, 3,5-Diiodothyropropionic acid inhibits SARS-CoV-2 3CL-Pro protease by 45.76% and 12.63% at a 20 µM concentration, evaluated through FRET assays. It also shows inhibitory activity against human HDAC6, with 9.91% inhibition using a commercial peptide substrate and 2.73% using a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1).
Synonyms	Ditpa cpd, C082182

Chemical Properties

Molecular Weight	510.06
Formula	C₁₅H₁₂I₂O₄
Cas No.	1158-10-7
Smiles	OC(=O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1
Relative Density.	2.068g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 140 mg/mL (274.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9606 mL	9.8028 mL	19.6055 mL	98.0277 mL
5 mM	0.3921 mL	1.9606 mL	3.9211 mL	19.6055 mL
10 mM	0.1961 mL	0.9803 mL	1.9606 mL	9.8028 mL
20 mM	0.0980 mL	0.4901 mL	0.9803 mL	4.9014 mL
50 mM	0.0392 mL	0.1961 mL	0.3921 mL	1.9606 mL
100 mM	0.0196 mL	0.0980 mL	0.1961 mL	0.9803 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc