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RIPK1-IN-7

Name: RIPK1-IN-7
Brand: TargetMol
SKU: T12731
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12731Cas No. 2300982-44-7

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1 (Kd of 4 nM and enzymatic IC50 of 11 nM), exhibiting excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.

RIPK1-IN-7

🥰Excellent

Purity: 98.18%

Catalog No. T12731Cas No. 2300982-44-7

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1 (Kd of 4 nM and enzymatic IC50 of 11 nM), exhibiting excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$228	In Stock
10 mg	$347	In Stock
25 mg	$538	In Stock
50 mg	$745	In Stock
100 mg	$993	In Stock
1 mL x 10 mM (in DMSO)	$245	In Stock

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Purity:98.18%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1 (Kd of 4 nM and enzymatic IC50 of 11 nM), exhibiting excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
Targets&IC50	RIPK1:(kd)4 nM , RIPK1:11 nM
In vitro	In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).

Chemical Properties

Molecular Weight	481.47
Formula	C₂₅H₂₂F₃N₅O₂
Cas No.	2300982-44-7
Smiles	CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
Relative Density.	1.42 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (124.62 mM), Sonication is recommended.

H2O: 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0770 mL	10.3849 mL	20.7697 mL	103.8486 mL
5 mM	0.4154 mL	2.0770 mL	4.1539 mL	20.7697 mL
10 mM	0.2077 mL	1.0385 mL	2.0770 mL	10.3849 mL
20 mM	0.1038 mL	0.5192 mL	1.0385 mL	5.1924 mL
50 mM	0.0415 mL	0.2077 mL	0.4154 mL	2.0770 mL
100 mM	0.0208 mL	0.1038 mL	0.2077 mL	1.0385 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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