Shopping Cart
Remove All
Your shopping cart is currently empty
RO9021
Copy Product Info
🥰Excellent
Catalog No. T16776Cas No. 1446790-62-0
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor [average IC50: 5.6 nM].
RO9021
Copy Product Info🥰Excellent
Purity: 99.90%
Catalog No. T16776Cas No. 1446790-62-0
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor [average IC50: 5.6 nM].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | In Stock | In Stock | |
| 5 mg | $98 | In Stock | In Stock | |
| 10 mg | $147 | In Stock | In Stock | |
| 25 mg | $247 | In Stock | In Stock | |
| 50 mg | $355 | In Stock | In Stock | |
| 100 mg | $479 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.90%
Appearance:Solid
Color:Orange
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor [average IC50: 5.6 nM]. |
| Targets&IC50 | Syk:5.6 nM |
| In vitro | RO9021 effectively inhibits the anti-IgM induced phosphorylation of key signaling proteins including BTK, PLCγ2, AKT, and ERK, thereby demonstrating its capacity to block SYK kinase activity and consequently attenuate the B-cell receptor (BCR) downstream signaling cascade. This compound selectively targets B-cell receptor signaling, underscored by its role as a highly selective inhibitor of SYK. Its selectivity is evidenced by low S-scores of 0.003 for S(99) and 0.015 for S(90), indicating that among 392 kinases tested, SYK is the sole kinase significantly competed by RO9021 with 99% effectiveness. Moreover, RO9021 exhibits comparable inhibitory potency (IC50=22.8±1.7 nM) in assays measuring FcεR-mediated mast cell activation and degranulation, highlighting its broad potential in modulating immune responses [1]. |
| Molecular Weight | 355.44 |
| Formula | C18H25N7O |
| Cas No. | 1446790-62-0 |
| Smiles | Cc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)nc1C |
| Relative Density. | 1.288 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 3 mg/mL (8.44 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
| ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy RO9021 | purchase RO9021 | RO9021 cost | order RO9021 | RO9021 chemical structure | RO9021 in vitro | RO9021 formula | RO9021 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.