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Demecarium bromide

Name: Demecarium bromide
Brand: TargetMol
SKU: T7213
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7213Cas No. 56-94-0

Alias BC-48

Demecarium bromide (BC-48) is a potent cholinesterase inhibitor,and is treatment glaucoma agent.

Demecarium bromide

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Catalog No. T7213Alias BC-48Cas No. 56-94-0

Demecarium bromide (BC-48) is a potent cholinesterase inhibitor,and is treatment glaucoma agent.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	-	In Stock
10 mg	$50	-	In Stock
25 mg	$82	-	In Stock
50 mg	$115	-	In Stock
100 mg	$156	-	In Stock
1 mL x 10 mM (in DMSO)	$57	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Demecarium bromide AI Summary

Demecarium bromide exhibits various bioactivities, demonstrating notable inhibitory effects against Mycobacterium tuberculosis with an IC50 of 1490.0 nM in 7H9 media and 2170.0 nM in the absence of glycerol. It also acts as a delayed death inhibitor of the malarial parasite plastid with values of 73.8 nM (96-hour incubation) and 116.9 nM (48-hour incubation). Additionally, Demecarium bromide inhibits Cell Surface uPA Generation with a potency value of 5623.4 nM. In assays related to Hepatitis C Virus (HCV), it shows potency as an inhibitor with values of 11220.2 nM, 819.9 nM (in the absence of CPT for human tyrosyl-DNA phosphodiesterase 1), and 2310.9 nM (in the presence of CPT for human tyrosyl-DNA phosphodiesterase 1). The assessment using the DILIps dataset indicates that Demecarium bromide is Drug Induced Liver Injury (DILI) positive. Furthermore, it exhibits very low bioactivity in inhibiting cell viability, with an inhibition index of 0.01238, indicating minimal effectiveness in reducing the viability of Vero E6 cells infected with SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Demecarium bromide (BC-48) is a potent cholinesterase inhibitor,and is treatment glaucoma agent.
Targets&IC50	ChE:0.15 μM (Kiapp)
Synonyms	BC-48

Chemical Properties

Molecular Weight	716.59
Formula	C₃₂H₅₂Br₂N₄O₄
Cas No.	56-94-0
Smiles	[Br-].[Br-].CN(CCCCCCCCCCN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C)C(=O)Oc1cccc(c1)[N+](C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (223.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (5.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3955 mL	6.9775 mL	13.9550 mL	69.7749 mL
5 mM	0.2791 mL	1.3955 mL	2.7910 mL	13.9550 mL
10 mM	0.1395 mL	0.6977 mL	1.3955 mL	6.9775 mL
20 mM	0.0698 mL	0.3489 mL	0.6977 mL	3.4887 mL
50 mM	0.0279 mL	0.1395 mL	0.2791 mL	1.3955 mL
100 mM	0.0140 mL	0.0698 mL	0.1395 mL	0.6977 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc