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Anti-PD-1 Antibody (9Z376)
🥰Excellent
Catalog No. TMAY-03117
Anti-PD-1 Antibody (9Z376) is a Rabbit antibody targeting PD-1. Anti-PD-1 Antibody (9Z376) can be used in FCM.
Anti-PD-1 Antibody (9Z376)
Anti-PD-1 Antibody (9Z376)
🥰Excellent
Catalog No. TMAY-03117
Anti-PD-1 Antibody (9Z376) is a Rabbit antibody targeting PD-1. Anti-PD-1 Antibody (9Z376) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PD-1 Antibody (9Z376) is a Rabbit antibody targeting PD-1. Anti-PD-1 Antibody (9Z376) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 9Z376 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse PD-1 expression on ConA-stimulated BABL/c splenocytes. Cells were stained with purified anti-Mouse PD-1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PD-1 / PDCD1 (rM PD-1 / PDCD1; TMPY-00996; NP_032824.1; Met1-Gln167). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Blockade: Blocking AntibodiImmune Checkpoint Blockade: PD1 / PDCD1 / CD2Immune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyPD1 / PDCD1 / CD279 Immune CheckpointPD1 / PDCD1 / CD279 Immune Checkpoint AntibodPD1 / PDCD1 / CD279 Immune Checkpoint ProteinTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | FITC |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Mouse PD-1 / PDCD1 Protein (TMPY-00996) |
| Antigen Species | Mouse |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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