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Tegafur
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Catalog No. T1378Cas No. 17902-23-7
Alias NSC 148958, FT-207, FT 207, Fluorafur
Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme.
Tegafur
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Purity: 99.89%
Catalog No. T1378Alias NSC 148958, FT-207, FT 207, FluorafurCas No. 17902-23-7
Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $30 | In Stock | In Stock | |
| 50 mg | $37 | In Stock | In Stock | |
| 100 mg | $53 | In Stock | In Stock | |
| 500 mg | $97 | - | In Stock | |
| 1 g | $139 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
Tegafur AI Summary
Tegafur exhibits a wide range of bioactivities, notably its significant antitumor effects across various cancer cell lines and models. It prolongs survival in mice bearing lymphocytic leukemia and inhibits tumor growth in both in vivo and in vitro settings. Specifically, it shows dose-dependent cytotoxicity against L1210 cells and exhibits inhibition percentages in human A549 and Ec9706 cells. The compound also demonstrates efficacy against human LS1034, HT29, BXPC3, SK-ES, Pan02, and U251 cells, as well as mouse CT26 cells, with observed changes in histone acetylation levels indicating HDAC inhibition.
Tegafur has also shown antibacterial and antifungal activities, with specific activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, among others. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease and shows some antiviral action against SARS-CoV-2, although with moderate efficacy.
The compound has been tested for its effects on biomarkers related to metabolic and organ function, including glucose levels, ALP, AST activity, and bilirubin concentration, suggesting broad systemic effects. It also exhibits liver toxicities, including moderate to severe liver damage, cirrhosis, and hepatitis, and affects body weight in animal models.
Despite its broad bioactivity spectrum, the compound shows limited brain penetration and specific partition coefficients, indicating varying affinity to different tissues and environments. Overall, Tegafur presents as a multi-faceted bioactive agent with substantial potential for antitumor and antimicrobial applications, albeit with associated toxicity considerations..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. |
| Synonyms | NSC 148958, FT-207, FT 207, Fluorafur |
| Molecular Weight | 200.17 |
| Formula | C8H9FN2O3 |
| Cas No. | 17902-23-7 |
| Smiles | O=C1N(C=C(F)C(=O)N1)C2CCCO2 |
| Relative Density. | 1.3222 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (249.79 mM), Sonication is recommended.  Ethanol: 7 mg/mL (34.97 mM), Sonication is recommended. H2O: 8 mg/mL (39.97 mM), Sonication is recommended. | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.99 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol/H2O/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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