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Anti-NBL1 Antibody (2R803)
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Catalog No. TMAY-00392
Alias NO3, neuroblastoma 1, DAN family BMP antagonist, Dana, DAN, D4H1S1733E
Anti-NBL1 Antibody (2R803) is a Mouse antibody targeting NBL1. Anti-NBL1 Antibody (2R803) can be used in ELISA(Det),IHC-P.
Anti-NBL1 Antibody (2R803)
Anti-NBL1 Antibody (2R803)
😃Good
Catalog No. TMAY-00392Alias NO3, neuroblastoma 1, DAN family BMP antagonist, Dana, DAN, D4H1S1733E
Anti-NBL1 Antibody (2R803) is a Mouse antibody targeting NBL1. Anti-NBL1 Antibody (2R803) can be used in ELISA(Det),IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $70 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-NBL1 Antibody (2R803) is a Mouse antibody targeting NBL1. Anti-NBL1 Antibody (2R803) can be used in ELISA(Det),IHC-P. |
| Alias | NO3, neuroblastoma 1, DAN family BMP antagonist, Dana, DAN, D4H1S1733E |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2R803 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human DAN in human lung with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). 2. Immunochemical staining of human DAN in human liver with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). 3. Immunochemical staining of human DAN in human kidney with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). |
| Application | ELISA(Det),IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200; ELISA(Det): 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NBL1 / DAND1 / DAN (rh NBL1 / DAND1 / DAN; TMPY-01039; NP_005371.1; Met1-Asp180). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in the vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression, and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante, and PRDC (protein related to DAN and Cerberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in the regulation of the entry of cells into the S phase. Besides, the DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumor suppressor gene for neuroblastoma. |
| Conjucates | Unconjugated |
| Others Formats | HRP |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human NBL1 / DAND1 / DAN protein (TMPY-01039) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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