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AMG131

Name: AMG131
Brand: TargetMol
SKU: T8780
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8780Cas No. 315224-26-1

Alias INT-131, CHS 131, AMG-131

AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes)

AMG131

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Purity: 99.37%

Catalog No. T8780Alias INT-131, CHS 131, AMG-131Cas No. 315224-26-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$428	In Stock	In Stock
100 mg	$639	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.37%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

AMG131 AI Summary

AMG131 exhibits a range of bioactivities related to its antidiabetic effects and modulation of PPARgamma. It displaces rosiglitazone from PPARgamma LBD with potent Ki values between 10.0 nM and 17.0 nM. This compound decreases blood glucose levels in Zucker fatty rats (ED30 of 0.3 mg/kg/day) and KKAy diabetic mouse models (60% reduction), while also reducing insulin levels in the latter at a dose of 30 mg/kg/day. In terms of weight gain, it increases body weight by 170.0% in KKAy mice at 30 mg/kg/day and by 42.0% in Zucker fatty rats at 3 mg/kg/day. Its efficacy relative to rosiglitazone varies, showing 24.0% to 40.0% in transactivation assays and it also has an agonist activity with EC50 values ranging from 4.0 nM to 500.0 nM, depending on the assay and cell type. Pharmacokinetic studies indicate dose-dependent AUC and Cmax in Sprague-Dawley rats. The compound also exhibits a moderate inhibitory effect on CYP3A4 with an IC50 of 25000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes)
Synonyms	INT-131, CHS 131, AMG-131

Chemical Properties

Molecular Weight	514.21
Formula	C₂₁H₁₂Cl₄N₂O₃S
Cas No.	315224-26-1
Smiles	Clc1ccc(c(Cl)c1)S(=O)(=O)Nc1cc(Cl)c(Oc2cnc3ccccc3c2)c(Cl)c1
Relative Density.	1.585 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (53.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9447 mL	9.7237 mL	19.4473 mL	97.2365 mL
5 mM	0.3889 mL	1.9447 mL	3.8895 mL	19.4473 mL
10 mM	0.1945 mL	0.9724 mL	1.9447 mL	9.7237 mL
20 mM	0.0972 mL	0.4862 mL	0.9724 mL	4.8618 mL
50 mM	0.0389 mL	0.1945 mL	0.3889 mL	1.9447 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc