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AMG131

Name: AMG131
Brand: TargetMol
SKU: T8780
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8780Cas No. 315224-26-1

Alias INT-131, CHS 131, AMG-131

AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes)

AMG131

🥰Excellent

Purity: 99.37%

Catalog No. T8780Alias INT-131, CHS 131, AMG-131Cas No. 315224-26-1

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$263	In Stock
50 mg	$428	In Stock
100 mg	$639	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock

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Batch Information

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Purity:99.37%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes)
Synonyms	INT-131, CHS 131, AMG-131

Chemical Properties

Molecular Weight	514.21
Formula	C₂₁H₁₂Cl₄N₂O₃S
Cas No.	315224-26-1
Smiles	Clc1ccc(c(Cl)c1)S(=O)(=O)Nc1cc(Cl)c(Oc2cnc3ccccc3c2)c(Cl)c1
Relative Density.	1.585 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (53.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9447 mL	9.7237 mL	19.4473 mL	97.2365 mL
5 mM	0.3889 mL	1.9447 mL	3.8895 mL	19.4473 mL
10 mM	0.1945 mL	0.9724 mL	1.9447 mL	9.7237 mL
20 mM	0.0972 mL	0.4862 mL	0.9724 mL	4.8618 mL
50 mM	0.0389 mL	0.1945 mL	0.3889 mL	1.9447 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc