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TNIK-IN-5

🥰Excellent
Catalog No. T9810Cas No. 2754265-66-0

TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.

TNIK-IN-5

TNIK-IN-5

🥰Excellent
Purity: 99.58%
Catalog No. T9810Cas No. 2754265-66-0
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$129In StockIn Stock
5 mg$322In StockIn Stock
10 mg$479In StockIn Stock
25 mg$818In StockIn Stock
50 mg$1,130In StockIn Stock
100 mg$1,530-In Stock
500 mg$2,970-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.58%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.
Chemical Properties
Molecular Weight371.39
FormulaC22H17N3O3
Cas No.2754265-66-0
SmilesC(N1C=2C(=CC(=CC2)C=3C=C4C(=NC3)NC=C4)OC1=O)C5=CC(OC)=CC=C5
Relative Density.1.373 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (26.93 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6926 mL13.4629 mL26.9259 mL134.6294 mL
5 mM0.5385 mL2.6926 mL5.3852 mL26.9259 mL
10 mM0.2693 mL1.3463 mL2.6926 mL13.4629 mL
20 mM0.1346 mL0.6731 mL1.3463 mL6.7315 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

βcateninWnt/β-cateninWnt/betacateninWnt/b-cateninWnt pathwayWntTNIK-IN-5TNIKIN5TNIK IN 5TNIKMigrationInhibitorinhibitHCT116?cellsColorectal cancerCell proliferationbeta-cateninbetacateninbcatenin
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