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Anti-CSK Antibody (8D601)
😃Good
Catalog No. TMAB-04726
Anti-CSK Antibody (8D601) is a Rabbit antibody targeting CSK. Anti-CSK Antibody (8D601) can be used in WB.
Anti-CSK Antibody (8D601)
Anti-CSK Antibody (8D601)
😃Good
Catalog No. TMAB-04726
Anti-CSK Antibody (8D601) is a Rabbit antibody targeting CSK. Anti-CSK Antibody (8D601) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CSK Antibody (8D601) is a Rabbit antibody targeting CSK. Anti-CSK Antibody (8D601) can be used in WB. |
| Ig Type | IgG |
| Clone | 8D601 |
| Reactivity | Human,Mouse (predicted:Rat) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts. |
| Tissue Specificity | Expressed in lung and macrophages. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites. |
| Immunogen | A synthesized peptide: human CSK |
| Antigen Species | Human |
| Gene Name | CSK |
| Gene ID | |
| Protein Name | Tyrosine-protein kinase CSK |
| Uniprot ID | |
| Function | Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases. |
| Molecular Weight | Theoretical: 51 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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