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Sesamin

Name: Sesamin
Brand: TargetMol
SKU: T2919
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2919Cas No. 607-80-7

Alias Fsesamin

Sesamin is a selective delta 5 desaturase inhibitor in the biosynthesis of polyunsaturated fatty acids and is a lignan abundantly present in sesame oil. It has potent neuroprotective effects against cerebral ischemia.

Sesamin

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Purity: 99.86%

Catalog No. T2919Alias FsesaminCas No. 607-80-7

Pack Size	Price	Availability
5 mg	$37	In Stock
10 mg	$50	In Stock
25 mg	$68	In Stock
50 mg	$98	In Stock
100 mg	$146	In Stock
500 mg	$359	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Purity:99.86%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Sesamin is a selective delta 5 desaturase inhibitor in the biosynthesis of polyunsaturated fatty acids and is a lignan abundantly present in sesame oil. It has potent neuroprotective effects against cerebral ischemia.
In vitro	In mice, the LD50 of orally administered sesamin is 3800 mg/kg; in rats, the LD50 is 6150 mg/kg.
In vivo	Sesamin significantly enhances the activity of liver enzymes involved in fatty acid oxidation, such as Acyl-CoA dehydrogenase, Acyl-CoA oxidase, 3-Hydroxyacyl-CoA dehydrogenase, Enoyl-CoA hydratase, and 3-Ketoacyl-CoA thiolase, as well as the activities of 2,4-Dienoyl-CoA reductase and Δ3,Δ2-Enoyl-CoA isomerase.
Synonyms	Fsesamin

Chemical Properties

Molecular Weight	354.35
Formula	C₂₀H₁₈O₆
Cas No.	607-80-7
Smiles	[C@]12([C@@]([C@H](OC1)C=3C=C4C(=CC3)OCO4)(CO[C@@H]2C=5C=C6C(=CC5)OCO6)[H])[H]
Relative Density.	1.385 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 103 mg/mL (290.67 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8221 mL	14.1103 mL	28.2207 mL	141.1034 mL
5 mM	0.5644 mL	2.8221 mL	5.6441 mL	28.2207 mL
10 mM	0.2822 mL	1.4110 mL	2.8221 mL	14.1103 mL
20 mM	0.1411 mL	0.7055 mL	1.4110 mL	7.0552 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL	2.8221 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc