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Drinabant

Name: Drinabant
Brand: TargetMol
SKU: T21861
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21861Cas No. 358970-97-5

Alias AVE-1625, AVE1625

Drinabant (AVE-1625) is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.

Drinabant

🥰Excellent

Purity: 99.8%

Catalog No. T21861Alias AVE-1625, AVE1625Cas No. 358970-97-5

Pack Size	Price	Availability
1 mg	$73	In Stock
5 mg	$160	In Stock
10 mg	$247	In Stock
25 mg	$409	In Stock
50 mg	$596	In Stock
100 mg	$848	In Stock
200 mg	$1,130	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.8%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Drinabant (AVE-1625) is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.
Targets&IC50	CB1 receptor (rat):10 nM, CB2:10000 nM, CB1 receptor (human):25 nM
In vivo	Drinabant (10 mg/kg orally once daily), combined with Olanzapine attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility[2]. Drinabant (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory[3].
Synonyms	AVE-1625, AVE1625

Chemical Properties

Molecular Weight	497.38
Formula	C₂₃H₂₀Cl₂F₂N₂O₂S
Cas No.	358970-97-5
Smiles	C(N1CC(N(S(C)(=O)=O)C2=CC(F)=CC(F)=C2)C1)(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4
Relative Density.	1.458 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (100.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0105 mL	10.0527 mL	20.1054 mL	100.5268 mL
5 mM	0.4021 mL	2.0105 mL	4.0211 mL	20.1054 mL
10 mM	0.2011 mL	1.0053 mL	2.0105 mL	10.0527 mL
20 mM	0.1005 mL	0.5026 mL	1.0053 mL	5.0263 mL
50 mM	0.0402 mL	0.2011 mL	0.4021 mL	2.0105 mL
100 mM	0.0201 mL	0.1005 mL	0.2011 mL	1.0053 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc