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Drinabant

Name: Drinabant
Brand: TargetMol
SKU: T21861
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21861Cas No. 358970-97-5

Alias AVE-1625, AVE1625

Drinabant (AVE-1625) is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.

Drinabant

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Purity: 99.8%

Catalog No. T21861Alias AVE-1625, AVE1625Cas No. 358970-97-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
5 mg	$160	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$409	In Stock	In Stock
50 mg	$596	In Stock	In Stock
100 mg	$848	In Stock	In Stock
200 mg	$1,130	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.8%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Drinabant (AVE-1625) is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.
Targets&IC50	CB1 receptor (rat):10 nM, CB2:10000 nM, CB1 receptor (human):25 nM
In vivo	Drinabant (10 mg/kg orally once daily), combined with Olanzapine attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility[2]. Drinabant (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory[3].
Synonyms	AVE-1625, AVE1625

Chemical Properties

Molecular Weight	497.38
Formula	C₂₃H₂₀Cl₂F₂N₂O₂S
Cas No.	358970-97-5
Smiles	C(N1CC(N(S(C)(=O)=O)C2=CC(F)=CC(F)=C2)C1)(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4
Relative Density.	1.458 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (100.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0105 mL	10.0527 mL	20.1054 mL	100.5268 mL
5 mM	0.4021 mL	2.0105 mL	4.0211 mL	20.1054 mL
10 mM	0.2011 mL	1.0053 mL	2.0105 mL	10.0527 mL
20 mM	0.1005 mL	0.5026 mL	1.0053 mL	5.0263 mL
50 mM	0.0402 mL	0.2011 mL	0.4021 mL	2.0105 mL
100 mM	0.0201 mL	0.1005 mL	0.2011 mL	1.0053 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc