Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 428.00 | |
25 mg | In stock | $ 686.00 | |
50 mg | In stock | $ 969.00 | |
100 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 2,620.00 |
Description | PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death. |
Targets&IC50 | GPX4:4.7(pEC50) |
In vitro |
PKUMDL-LC-101-D04 (20 μM) increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay.[1] PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.[1] |
Synonyms | GPX4-Activator-1d4, PKUMDL-LC-101-D04 |
Molecular Weight | 378.94 |
Formula | C14H23ClN4O2S2 |
CAS No. | 2143896-83-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (593.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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PKUMDL-LC-101-D04 2143896-83-5 oxidation-reduction GPX GPX4-Activator-1d4 inhibitor inhibit