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PKUMDL-LC-101-D04

Name: PKUMDL-LC-101-D04
Brand: TargetMol
SKU: T36935
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36935Cas No. 2143896-83-5

Alias PKUMDL-LC-101-D04, GPX4-Activator-1d4

PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.

PKUMDL-LC-101-D04

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Purity: 99.65%

Catalog No. T36935Alias PKUMDL-LC-101-D04, GPX4-Activator-1d4Cas No. 2143896-83-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
5 mg	$162	In Stock	In Stock
10 mg	$275	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$569	In Stock	In Stock
100 mg	$786	In Stock	In Stock
200 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
Targets&IC50	GPX4:4.7(pEC50)
In vitro	PKUMDL-LC-101-D04 (20 μM) increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay.[1] PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.[1]
Synonyms	PKUMDL-LC-101-D04, GPX4-Activator-1d4

Chemical Properties

Molecular Weight	378.94
Formula	C₁₄H₂₃ClN₄O₂S₂
Cas No.	2143896-83-5
Smiles	Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (593.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6389 mL	13.1947 mL	26.3894 mL	131.9470 mL
5 mM	0.5278 mL	2.6389 mL	5.2779 mL	26.3894 mL
10 mM	0.2639 mL	1.3195 mL	2.6389 mL	13.1947 mL
20 mM	0.1319 mL	0.6597 mL	1.3195 mL	6.5974 mL
50 mM	0.0528 mL	0.2639 mL	0.5278 mL	2.6389 mL
100 mM	0.0264 mL	0.1319 mL	0.2639 mL	1.3195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc