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Anti-LRPAP1 Antibody (8W851)
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Catalog No. TMAY-01638
Alias RAP, low density lipoprotein receptor-related protein associated protein 1, HBP44, C77774, AU042172, AI790446, AA617339
Anti-LRPAP1 Antibody (8W851) is a Mouse antibody targeting LRPAP1. Anti-LRPAP1 Antibody (8W851) can be used in IHC-P.
Anti-LRPAP1 Antibody (8W851)
Anti-LRPAP1 Antibody (8W851)
😃Good
Catalog No. TMAY-01638Alias RAP, low density lipoprotein receptor-related protein associated protein 1, HBP44, C77774, AU042172, AI790446, AA617339
Anti-LRPAP1 Antibody (8W851) is a Mouse antibody targeting LRPAP1. Anti-LRPAP1 Antibody (8W851) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-LRPAP1 Antibody (8W851) is a Mouse antibody targeting LRPAP1. Anti-LRPAP1 Antibody (8W851) can be used in IHC-P. |
| Alias | RAP, low density lipoprotein receptor-related protein associated protein 1, HBP44, C77774, AU042172, AI790446, AA617339 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8W851 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human LRPAP1 in human kidney with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule. 2. Immunochemical staining of human LRPAP1 in human hepatoma with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human LRPAP1 in human brain with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. Alpha-2-macroglobulin receptor-associated protein, also known as low-density lipoprotein receptor-related protein-associated protein 1, RAP, and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the low-density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on the cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330) and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin. Intron 5 insertion/deletion polymorphism of RAP gene (LRPAP1) has been implicated in other diseases sharing etiology with gallstone disease (GSD). The LRPAP1 insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiasis. The genetic variations at the LRPAP1 locus may modulate Alzheimer's disease (AD) phenotype beyond risk for disease. Also, the variation in the LRPAP1 gene could contribute to the risk of developing an early episode of myocardial infarction (MI). |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human LRPAP1 protein (TMPY-01233) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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