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PS372424 hydrochloride

Name: PS372424 hydrochloride
Brand: TargetMol
SKU: T64661
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64661Cas No. 1596362-29-6

Alias PS 372424 hydrochloride

PS372424 hydrochloride is a three-amino-acid fragment of CXCL10 that functions as a specific human CXCR3 agonist with anti-inflammatory activity, capable of inhibiting human T-cell migration in humanized arthritic inflammation models.

PS372424 hydrochloride

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Purity: 95.03%

Catalog No. T64661Alias PS 372424 hydrochlorideCas No. 1596362-29-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$99	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95.03%

Appearance:Viscous

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	PS372424 hydrochloride is a three-amino-acid fragment of CXCL10 that functions as a specific human CXCR3 agonist with anti-inflammatory activity, capable of inhibiting human T-cell migration in humanized arthritic inflammation models.
In vitro	In cells expressing CXCR3-A, stimulation with PS372424 hydrochloride resulted in a peak in intracellular calcium levels after 20 seconds, and after 5 minutes of stimulation, PS372424 increased phosphorylated p-Erk1 and phosphorylated p-Erk2 in U87-CXCR3-A cells.[1]
Synonyms	PS 372424 hydrochloride

Chemical Properties

Molecular Weight	625.2
Formula	C₃₃H₄₅ClN₆O₄
Cas No.	1596362-29-6
Smiles	C(N[C@H](C(NCC1CCCCC1)=O)CCCNC(=N)N)(=O)[C@H]2N(C(CCC(=O)C3=CC=CC=C3)=O)CC=4C(C2)=CC=CC4.Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (319.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5995 mL	7.9974 mL	15.9949 mL	79.9744 mL
5 mM	0.3199 mL	1.5995 mL	3.1990 mL	15.9949 mL
10 mM	0.1599 mL	0.7997 mL	1.5995 mL	7.9974 mL
20 mM	0.0800 mL	0.3999 mL	0.7997 mL	3.9987 mL
50 mM	0.0320 mL	0.1599 mL	0.3199 mL	1.5995 mL
100 mM	0.0160 mL	0.0800 mL	0.1599 mL	0.7997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc