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PS372424 hydrochloride

Name: PS372424 hydrochloride
Brand: TargetMol
SKU: T64661
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64661Cas No. 1596362-29-6

Alias PS 372424 hydrochloride

PS372424 hydrochloride is a three-amino-acid fragment of CXCL10 that functions as a specific human CXCR3 agonist with anti-inflammatory activity, capable of inhibiting human T-cell migration in humanized arthritic inflammation models.

PS372424 hydrochloride

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Purity: 95.03%

Catalog No. T64661Alias PS 372424 hydrochlorideCas No. 1596362-29-6

Pack Size	Price	Availability	Quantity
1 mg	$99	In Stock

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Purity:95.03%

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Product Introduction

Bioactivity

Description	PS372424 hydrochloride is a three-amino-acid fragment of CXCL10 that functions as a specific human CXCR3 agonist with anti-inflammatory activity, capable of inhibiting human T-cell migration in humanized arthritic inflammation models.
In vitro	In cells expressing CXCR3-A, stimulation with PS372424 hydrochloride resulted in a peak in intracellular calcium levels after 20 seconds, and after 5 minutes of stimulation, PS372424 increased phosphorylated p-Erk1 and phosphorylated p-Erk2 in U87-CXCR3-A cells.[1]
Synonyms	PS 372424 hydrochloride

Chemical Properties

Molecular Weight	625.2
Formula	C₃₃H₄₅ClN₆O₄
Cas No.	1596362-29-6
Smiles	C(N[C@H](C(NCC1CCCCC1)=O)CCCNC(=N)N)(=O)[C@H]2N(C(CCC(=O)C3=CC=CC=C3)=O)CC=4C(C2)=CC=CC4.Cl
Color	Transparent
Appearance	Viscous

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (319.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5995 mL	7.9974 mL	15.9949 mL	79.9744 mL
5 mM	0.3199 mL	1.5995 mL	3.1990 mL	15.9949 mL
10 mM	0.1599 mL	0.7997 mL	1.5995 mL	7.9974 mL
20 mM	0.0800 mL	0.3999 mL	0.7997 mL	3.9987 mL
50 mM	0.0320 mL	0.1599 mL	0.3199 mL	1.5995 mL
100 mM	0.0160 mL	0.0800 mL	0.1599 mL	0.7997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc