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Anti-Neuropilin-1 Antibody (8A380)
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Catalog No. TMAY-00059
Alias VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4
Anti-Neuropilin-1 Antibody (8A380) is a Rabbit antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody (8A380) can be used in ELISA,IHC-P.
Anti-Neuropilin-1 Antibody (8A380)
Anti-Neuropilin-1 Antibody (8A380)
😃Good
Catalog No. TMAY-00059Alias VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4
Anti-Neuropilin-1 Antibody (8A380) is a Rabbit antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody (8A380) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
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Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, IHC-P Reactivity: Human |
| Alias | VEGF165R, NRP, NP1, Neuropilin-1, neuropilin 1, CD304, BDCA4 |
| Ig Type | Rabbit IgG |
| Clone | 8A380 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human NRP1 in human placenta with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human NRP1 in human heart with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human NRP1 in human brain with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Neuropilin-1 / NRP1 / CD304 (rh Neuropilin-1 / NRP1 / CD304; TMPY-02367; NP_001019799.1; Met1-Lys644). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Neuropilin-1 / NRP1 / CD304 protein (TMPY-02367) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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