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PF-04745637

Name: PF-04745637
Brand: TargetMol
SKU: T64337
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64337Cas No. 1917294-46-2

Alias PF-4745637, PF4745637, PF 4745637, PF 04745637

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM [1].

PF-04745637

🥰Excellent

Purity: 99.3%

Catalog No. T64337Alias PF-4745637, PF4745637, PF 4745637, PF 04745637Cas No. 1917294-46-2

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM [1].

Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$148	In Stock
10 mg	$207	In Stock
25 mg	$350	In Stock
50 mg	$500	In Stock
100 mg	$690	In Stock
200 mg	$928	In Stock
1 mL x 10 mM (in DMSO)	$166	In Stock

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Batch Information

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Purity:99.3%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM [1].
Targets&IC50	TRPA1:17 nM
In vivo	PF-04745637 (topically applied; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].
Synonyms	PF-4745637, PF4745637, PF 4745637, PF 04745637

Chemical Properties

Molecular Weight	509
Formula	C₂₇H₃₂ClF₃N₂O₂
Cas No.	1917294-46-2
Smiles	OC1(CCN(CC1)C(CNC(=O)C1(CCCC1)c1ccc(Cl)cc1)Cc1ccccc1)C(F)(F)F
Relative Density.	1.281 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (117.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9646 mL	9.8232 mL	19.6464 mL	98.2318 mL
5 mM	0.3929 mL	1.9646 mL	3.9293 mL	19.6464 mL
10 mM	0.1965 mL	0.9823 mL	1.9646 mL	9.8232 mL
20 mM	0.0982 mL	0.4912 mL	0.9823 mL	4.9116 mL
50 mM	0.0393 mL	0.1965 mL	0.3929 mL	1.9646 mL
100 mM	0.0196 mL	0.0982 mL	0.1965 mL	0.9823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc