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PI3Kα-IN-7
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Catalog No. T61967Cas No. 2417098-53-2
PI3Kα-IN-7 (Compound A12) is a potent inhibitor of PI3Kα and PI3Kβ, capable of reducing mitochondrial membrane potential in cancer cells and inducing apoptosis.
PI3Kα-IN-7
😃Good
Catalog No. T61967Cas No. 2417098-53-2
PI3Kα-IN-7 (Compound A12) is a potent inhibitor of PI3Kα and PI3Kβ, capable of reducing mitochondrial membrane potential in cancer cells and inducing apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PI3Kα-IN-7 (Compound A12) is a potent inhibitor of PI3Kα and PI3Kβ, capable of reducing mitochondrial membrane potential in cancer cells and inducing apoptosis. |
| In vitro | PI3Kα-IN-7 (Compound A12) exhibits strong anti-tumor activity across multiple cell lines, including HCT116, PC-3, MCF-7, A549, and MDA-MB-231, with respective IC50 values of 3.24 μM, 14.37 μM, 7.39 μM, 7.10 μM, and 16.85 μM [1]. |
| Molecular Weight | 402.47 |
| Formula | C17H22N8O2S |
| Cas No. | 2417098-53-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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