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[Orn8]-Urotensin II acetate

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Catalog No. T37527L

[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.

[Orn8]-Urotensin II acetate
Other Forms of [Orn8]-Urotensin II acetate:
[Orn8]-Urotensin IIT37527479065-85-5
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[Orn8]-Urotensin II acetate

🥰Excellent
Purity: 98.63%
Catalog No. T37527L
[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$195-In Stock
5 mg$437-In Stock
10 mg$646-In Stock
25 mg$987-In Stock
50 mg$1,380-In Stock
100 mg$1,860-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.63%
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COA HPLC MS

Product Introduction

Bioactivity
Description
[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.
Targets&IC50
UT receptor/GPR14:8 (pEC50)
In vivo
[Orn8]-Urotensin II acetate behaves as a full agonist (pEC50 approximately equal 8) at both human and rat UT receptors in the FlipR calcium assay eliciting similar maximal effects as the natural ligand U-II. On the contrary, in the rat aorta bioassay, [Orn8]-Urotensin II acetate behaves as a competitive and selective antagonist (pA2 = 6.56) showing however a small but consistent residual agonist activity[2].
Chemical Properties
Molecular Weight1434.59
FormulaC65H87N13O20S2
SmilesO=C([C@H]([C@@H](C)O)NC([C@@H](N)CCC(O)=O)=O)N(CCC1)[C@H]1C(N[C@H](CC(O)=O)C(N[C@H]2C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@H](C(N[C@H](C(C)C)C(O)=O)=O)CSSC2)=O)=O)CCCN)=O)=O)=O)=O)=O.CC(O)=O
SequenceGlu-Thr-Pro-Asp-Cys(1)-Phe-Trp-Orn-Tyr-Cys(1)-Val
Sequence ShortETPDCFWXYCV
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 14.35 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.6971 mL3.4853 mL6.9706 mL34.8532 mL
5 mM0.1394 mL0.6971 mL1.3941 mL6.9706 mL
10 mM0.0697 mL0.3485 mL0.6971 mL3.4853 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

Urotensin Receptor (GPR14)[Orn-8]-Urotensin II acetate(479065-85-5 Free base)[Orn8]-Urotensin II Acetate[Orn8]Urotensin II acetate[Orn8] Urotensin II acetate
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