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[Orn8]-Urotensin II acetate

Name: [Orn8]-Urotensin II acetate
Brand: TargetMol
SKU: T37527L
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37527L

[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.

[Orn8]-Urotensin II acetate

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Purity: 98.63%

Catalog No. T37527L

[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	-	In Stock
5 mg	$262	-	In Stock
10 mg	$388	-	In Stock
25 mg	$592	-	In Stock
50 mg	$828	-	In Stock
100 mg	$1,110	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.63%

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description	[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.
Targets&IC50	UT receptor/GPR14:8 (pEC50)
In vivo	[Orn8]-Urotensin II acetate behaves as a full agonist (pEC50 approximately equal 8) at both human and rat UT receptors in the FlipR calcium assay eliciting similar maximal effects as the natural ligand U-II. On the contrary, in the rat aorta bioassay, [Orn8]-Urotensin II acetate behaves as a competitive and selective antagonist (pA2 = 6.56) showing however a small but consistent residual agonist activity[2].

Chemical Properties

Molecular Weight	1434.59
Formula	C₆₅H₈₇N₁₃O₂₀S₂
Smiles	O=C([C@H]([C@@H](C)O)NC([C@@H](N)CCC(O)=O)=O)N(CCC1)[C@H]1C(N[C@H](CC(O)=O)C(N[C@H]2C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@H](C(N[C@H](C(C)C)C(O)=O)=O)CSSC2)=O)=O)CCCN)=O)=O)=O)=O)=O.CC(O)=O
Sequence	Glu-Thr-Pro-Asp-Cys(1)-Phe-Trp-Orn-Tyr-Cys(1)-Val
Sequence Short	ETPDCFWXYCV

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 14.35 mg/mL (10 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6971 mL	3.4853 mL	6.9706 mL	34.8532 mL
5 mM	0.1394 mL	0.6971 mL	1.3941 mL	6.9706 mL
10 mM	0.0697 mL	0.3485 mL	0.6971 mL	3.4853 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc