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Brimonidine

Name: Brimonidine
Brand: TargetMol
SKU: T20157
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20157Cas No. 59803-98-4

Alias Bromoxidine, AGN-190342, AGN190342, AGN 190342

Brimonidine (Bromoxidine) is a drug used as eye drops under the brand names Alphagan and Alphagan-P. It is used to treat open-angle glaucoma or ocular hypertension

Brimonidine

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Purity: 99.62%

Catalog No. T20157Alias Bromoxidine, AGN-190342, AGN190342, AGN 190342Cas No. 59803-98-4

Brimonidine (Bromoxidine) is a drug used as eye drops under the brand names Alphagan and Alphagan-P. It is used to treat open-angle glaucoma or ocular hypertension

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$156	In Stock	In Stock
500 mg	$389	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.62%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Brimonidine (Bromoxidine) is a drug used as eye drops under the brand names Alphagan and Alphagan-P. It is used to treat open-angle glaucoma or ocular hypertension
In vitro	[3H]Brimonidine is a full agonist at alpha 2-adrenergic receptors labeling at least 2 specific binding sites in the human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1].
Synonyms	Bromoxidine, AGN-190342, AGN190342, AGN 190342

Chemical Properties

Molecular Weight	292.13
Formula	C₁₁H₁₀BrN₅
Cas No.	59803-98-4
Smiles	BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12
Relative Density.	1.82 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (171.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4231 mL	17.1157 mL	34.2313 mL	171.1567 mL
5 mM	0.6846 mL	3.4231 mL	6.8463 mL	34.2313 mL
10 mM	0.3423 mL	1.7116 mL	3.4231 mL	17.1157 mL
20 mM	0.1712 mL	0.8558 mL	1.7116 mL	8.5578 mL
50 mM	0.0685 mL	0.3423 mL	0.6846 mL	3.4231 mL
100 mM	0.0342 mL	0.1712 mL	0.3423 mL	1.7116 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc