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Anti-Desmocollin 3 Antibody (4M116) is a Rabbit antibody targeting Desmocollin 3. Anti-Desmocollin 3 Antibody (4M116) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
| Description | Anti-Desmocollin 3 Antibody (4M116) is a Rabbit antibody targeting Desmocollin 3. Anti-Desmocollin 3 Antibody (4M116) can be used in WB. |
| Ig Type | IgG |
| Clone | 4M116 |
| Reactivity | Mouse,Rat (predicted:Human) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. Cell junction > desmosome. |
| Tissue Specificity | Epidermis, buccal mucosa, esophagus and cervix. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| Immunogen | A synthesized peptide: human Desmocollin 3 |
| Antigen Species | Human |
| Gene Name | DSC3 |
| Gene ID | |
| Protein Name | Desmocollin-3 |
| Uniprot ID | |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| Molecular Weight | Theoretical: 100 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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