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Anti-Desmocollin 3 Antibody (4M116)

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Catalog No. TMAB-05100

Anti-Desmocollin 3 Antibody (4M116) is a Rabbit antibody targeting Desmocollin 3. Anti-Desmocollin 3 Antibody (4M116) can be used in WB.

Anti-Desmocollin 3 Antibody (4M116)

Anti-Desmocollin 3 Antibody (4M116)

😃Good
Catalog No. TMAB-05100
Anti-Desmocollin 3 Antibody (4M116) is a Rabbit antibody targeting Desmocollin 3. Anti-Desmocollin 3 Antibody (4M116) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1507-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Desmocollin 3 Antibody (4M116) is a Rabbit antibody targeting Desmocollin 3. Anti-Desmocollin 3 Antibody (4M116) can be used in WB.
Ig Type
IgG
Clone
4M116
Reactivity
Mouse,Rat (predicted:Human)
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane. Cell junction > desmosome.
Tissue SpecificityEpidermis, buccal mucosa, esophagus and cervix.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundThe protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Antigen Details
Immunogen
A synthesized peptide: human Desmocollin 3
Antigen Species
Human
Gene Name
DSC3
Gene ID
Protein Name
Desmocollin-3
Uniprot ID
Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Chemical Properties
Molecular WeightTheoretical: 100 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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