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BLX3887

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Catalog No. T37273Cas No. 934758-70-0
Alias BLX-3887, BLX 3887

BLX3887 is a highly potent and selective inhibitor of 15-lipoxygenase type 1 (15-LO-1), exhibiting an IC50 of 32 nM in cell-free enzyme assays, with marked selectivity over 15-LO-2, which it does not inhibit, as well as over 5-LO (IC50 = 472 nM) and 12-LO (IC50 = 3,310 nM). BLX3887 selectively suppresses 15-LO metabolite production in eosinophils over neutrophils at 10 μM while additionally inhibiting endocytosis and migration of human peripheral blood mononuclear cell–derived dendritic cells in vitro, highlighting its utility in inflammatory and immune cell signaling research.

BLX3887

BLX3887

😃Good
Catalog No. T37273Alias BLX-3887, BLX 3887Cas No. 934758-70-0
BLX3887 is a highly potent and selective inhibitor of 15-lipoxygenase type 1 (15-LO-1), exhibiting an IC50 of 32 nM in cell-free enzyme assays, with marked selectivity over 15-LO-2, which it does not inhibit, as well as over 5-LO (IC50 = 472 nM) and 12-LO (IC50 = 3,310 nM). BLX3887 selectively suppresses 15-LO metabolite production in eosinophils over neutrophils at 10 μM while additionally inhibiting endocytosis and migration of human peripheral blood mononuclear cell–derived dendritic cells in vitro, highlighting its utility in inflammatory and immune cell signaling research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 μg$11335 days35 days
1 mg$21835 days35 days
5 mg$86235 days35 days
10 mg$1,53035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
BLX3887 is a highly potent and selective inhibitor of 15-lipoxygenase type 1 (15-LO-1), exhibiting an IC50 of 32 nM in cell-free enzyme assays, with marked selectivity over 15-LO-2, which it does not inhibit, as well as over 5-LO (IC50 = 472 nM) and 12-LO (IC50 = 3,310 nM). BLX3887 selectively suppresses 15-LO metabolite production in eosinophils over neutrophils at 10 μM while additionally inhibiting endocytosis and migration of human peripheral blood mononuclear cell–derived dendritic cells in vitro, highlighting its utility in inflammatory and immune cell signaling research.
Targets&IC50
15-LOX1:32 nM
In vitro
In functional assays utilizing human granulocytes, BLX3887 acted as a potent and selective inhibitor of 15-Lipoxygenase-1 (15-LOX-1), exhibiting an IC50 of 0.37 μM [1].
SynonymsBLX-3887, BLX 3887
Chemical Properties
Molecular Weight308.52
FormulaC10H5Cl3FN3O
Cas No.934758-70-0
SmilesO=C(NC1=CC=C(F)C=C1Cl)C2=NNC(Cl)=C2Cl
Relative Density.1.714 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 15 mg/mL (48.62 mM), Sonication is recommended.
DMSO: 8 mg/mL (25.93 mM), Sonication is recommended.
PBS (pH 7.2)(1:5): < 1 mg/mL (insoluble)
DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL (0.52 mM), Sonication is recommended.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

BLX3887
Related Tags: buy BLX3887 | purchase BLX3887 | BLX3887 cost | order BLX3887 | BLX3887 chemical structure | BLX3887 in vitro | BLX3887 formula | BLX3887 molecular weight
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