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BLX3887

Catalog No. T37273 CAS 934758-70-0

BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.

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BLX3887, CAS 934758-70-0

Pack Size	Availability	Price/USD
500 μg	35 days	$ 78.00
1 mg	35 days	$ 153.00
5 mg	35 days	$ 595.00
10 mg	35 days	$ 1,060.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	308.52
Formula	C10H5Cl3FN3O
CAS No.	934758-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 30 mg/mL

DMSO: 15 mg/mL

DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL

References and Literature

1. Archambault, A.-S., Turcotte, C., Martin, C., et al. Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils. PLoS One 13(8), e0202424 (2018).

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BLX3887 934758-70-0 BLX-3887 BLX 3887 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.