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Anti-IL-18BP Antibody (4K247)
😃Good
Catalog No. TMAY-00683
Alias interleukin 18 binding protein, IL18BPa
Anti-IL-18BP Antibody (4K247) is a Rabbit antibody targeting IL-18BP. Anti-IL-18BP Antibody (4K247) can be used in ELISA.
Anti-IL-18BP Antibody (4K247)
Anti-IL-18BP Antibody (4K247)
😃Good
Catalog No. TMAY-00683Alias interleukin 18 binding protein, IL18BPa
Anti-IL-18BP Antibody (4K247) is a Rabbit antibody targeting IL-18BP. Anti-IL-18BP Antibody (4K247) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL-18BP Antibody (4K247) is a Rabbit antibody targeting IL-18BP. Anti-IL-18BP Antibody (4K247) can be used in ELISA. |
| Alias | interleukin 18 binding protein, IL18BPa |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4K247 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL18BP / IL18BPa (rh IL18BP / IL18BPa ; TMPY-00846; NP_001034748.1; Met1-Gly194). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human IL18BP / IL18BPa protein (TMPY-00846) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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