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Cell Cycle/Checkpoint

Nucleoside Antimetabolite/Analog

Poly(ADP-ribose) Glycohydrolase (PARG)

Serine/threonin kinase

(107)

Wee1

(41)

Y Box Binding Protein 1

(4)

c-Myc

(119)

DNA Damage/DNA Repair

DNA Alkylator/Crosslinker

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands.

Filter HomeSignaling PathwaysDNA Damage/DNA Repair-Cell Cycle/CheckpointNucleoside Antimetabolite/Analog

Gemcitabine

NSC 613327, LY188011

T025195058-81-4

Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

Apoptosis Autophagy DNA/RNA Synthesis Nucleoside Antimetabolite/Analog

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5-BrdU

BUdR, Broxuridine, Bromodeoxyuridine, BRDU, 5-bromo-2'-deoxyuridine

T679459-14-3

5-BrdU (Broxuridine) is a nucleoside analogue. 5-BrdU is used to detect proliferating cells and compete with thymidine for incorporation into DNA.

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog

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5-Fluorouracil

NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil

T098451-21-8

5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.

Apoptosis DNA/RNA Synthesis Endogenous Metabolite HIV Protease Nucleoside Antimetabolite/Analog

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Decitabine

NSC 127716, Dacogen, 5-Aza-CdR, 5-Aza-2'-deoxycytidine

T15082353-33-5

Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.

Apoptosis DNA Methyltransferase Nucleoside Antimetabolite/Analog

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Fludarabine

NSC 118218, Fludarabinum, F-ara-A

T103821679-14-1

Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.

Apoptosis DNA/RNA Synthesis Nucleoside Antimetabolite/Analog STAT

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Sangivamycin

NSC 65346, BA-90912

T960518417-89-5

Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.

Nucleoside Antimetabolite/Analog PKC

$128

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Trifluridine/tipiracil hydrochloride mixture

Trifluridine-tipiracil hydrochloride mixture, TAS-102, TAS102, TAS 102

T3658733030-01-8

Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and tipiracil hydrochloride (TTP) in a 2:1 molar ratio.

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog

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Cytarabine

Cytosine β-D-arabinofuranoside, Cytosine Arabinoside, Ara-C, Arabinocytidine

T1272147-94-4

Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.

Apoptosis Autophagy DNA/RNA Synthesis Endogenous Metabolite HSV Nucleoside Antimetabolite/Analog Virus Protease

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5-Azacytidine

NSC 102816, Mylosar, Ladakamycin, Azacitidine, 5-AzaC

T1339320-67-2

5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autophagy and has antitumor activity.

Antibacterial Antibiotic Autophagy DNA Methyltransferase Nucleoside Antimetabolite/Analog

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Uridine

β-Uridine, Uridin, NSC 20256

T222158-96-8

Uridine (Uridin) is a nucleoside compound, one of the four bases that make up RNA, that replaces thymine in DNA during transcription and pairs with adenine.

Endogenous Metabolite NF-κB Nucleoside Antimetabolite/Analog

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Preq1-Dihydrochloride

pre-queuosine1 Dihydrochloride

T901286694-45-3

Preq1-Dihydrochloride (pre-queuosine1 Dihydrochloride) is an intermediate of the queuosine pathway, it binds with high affinity to the aptamer of PreQ1 riboswitch, which attenuates protein expression.

Nucleoside Antimetabolite/Analog Others

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Rabacfosadine

VDC-1101, GS-9219

T16716859209-74-8In house

Rabacfosadine (GS-9219) is a novel dual pre-drug of the acyclic nucleotide phosphonate PMEG to tumor lymphocytes for the study of lymphoma.

Nucleoside Antimetabolite/Analog

$129

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Forodesine

Immucillin-H, BCX-1777

T15337209799-67-7

Forodesine (BCX-1777) is an orally active and potent purine nucleoside phosphorylase (PNP) inhibitor, a new purine nucleoside analog, inhibitor of human lymphocyte proliferation, induces apoptosis in leukemic cells by increasing dGTP levels, and may be useful in the study of cutaneous T-cell lymphomas.

Apoptosis Nucleoside Antimetabolite/Analog

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Nelarabine

Nelzarabine, GW 506U78, 506U78

T6603121032-29-9

Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

Apoptosis DNA/RNA Synthesis Nucleoside Antimetabolite/Analog

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T6A

t-6-A, t(6)A, t 6 A, N6-Threonylcarbamoyladenosine, N-(6-Nebularinylcarbamoyl)threonine

T3476524719-82-2

T6A (N6-Threonylcarbamoyladenosine) is a ubiquitously conserved nucleoside, which is essential for modification. T6A is found in the tRNA responsible for transporting the ANN codon.

Nucleoside Antimetabolite/Analog Others

$172

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Fialuridine

FIAU, DRG-0098

T765569123-98-4

Fialuridine (DRG-0098) is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and in vivo.

DNA/RNA Synthesis HBV HSV Nucleoside Antimetabolite/Analog Virus Protease

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Gemcitabine hydrochloride

LY 188011 hydrochloride, Gemzar, Gemcitabine HCl

T6069122111-03-9

Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

Apoptosis Autophagy DNA/RNA Synthesis Nucleoside Antimetabolite/Analog

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Ascamycin

T1432991432-48-3In house

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It exhibits selective antibacterial activity against Xanthomonas species, inhibiting Xanthomonas citri, Xanthomonas oryzae, and phage with MIC values of 0.4 μg/mL, 12.5 μg/mL, and 12.5 μg/mL respectively.

Antibacterial Antibiotic Nucleoside Antimetabolite/Analog

$350

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Adenosine Dialdehyde (ADOX)

Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidized

T2223134240-05-6In house

Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.

Nucleoside Antimetabolite/Analog Others

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4-Thiouridine

T3564813957-31-8

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU

Nucleoside Antimetabolite/Analog Others

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Adenosine

D-Adenosine, Adenine riboside

T085358-61-7

Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.

Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog

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Peldesine

BCX 34

T12399133432-71-0In house

Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection.

HIV Protease Nucleoside Antimetabolite/Analog

$116

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5-Ethynyluridine

T3697169075-42-9

5-Ethynyluridine is a clickable form of uridine.1It is incorporated into cellular RNA, but not DNA, and has been used to detect transcriptionin vitroandin vivo. 1.Jao, C.Y., and Salic, A.Exploring RNA transcription and turnover in vivo by using click chemistryProc. Natl. Acad. Sci. USA105(41)15779-15784(2008)

Nucleoside Antimetabolite/Analog

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